Saikia Basanta, Chen Dong, de Coene Yovan, Van Cleuvenbergen Stijn
Department of Chemistry, Molecular Imaging and Photonics, KULAK-KU Leuven, E. Sabbelaan 53, 8500 Kortrijk, Belgium.
Department of Chemistry, Molecular Imaging and Photonics, KU Leuven, Celestijnenlaan 200D, 3001 Heverlee, Belgium.
Gels. 2024 Nov 19;10(11):749. doi: 10.3390/gels10110749.
FmocFF (9-fluorenyl methoxycarbonyl-phenylalanine) is an extensively studied low-molecular-weight hydrogel. Although there have been numerous studies on FmocFF hydrogel, its potential to form organogels has not been well explored. In this work, we systematically explore the organogels of FmocFF in a wide range of organic solvents. FmocFF is found to be a robust organogeltor, and the subsequent organogels exhibit diverse gelmorphic behavior exhibiting various degrees of crystallinity and morphology depending on the solvent used. The mechanical strength of the organogels is evaluated using rheology. A novel technique, in situ SHG microscopy, is introduced to study the gel structure in its native state. In addition to the solvent-solute interactions that are typically used to predict gelmorphic behavior, we observed indications that the degree of crystallinity also plays a significant role in determining the mechanical properties and structure of FmocFF organogels.
芴甲氧羰基苯丙氨酸（FmocFF）是一种经过广泛研究的低分子量水凝胶。尽管对FmocFF水凝胶已有众多研究，但其形成有机凝胶的潜力尚未得到充分探索。在这项工作中，我们系统地研究了FmocFF在多种有机溶剂中的有机凝胶。发现FmocFF是一种强大的有机凝胶剂，随后形成的有机凝胶表现出多样的凝胶形态行为，根据所使用的溶剂不同，呈现出不同程度的结晶度和形态。使用流变学评估有机凝胶的机械强度。引入了一种新技术——原位二次谐波显微镜，以研究其原始状态下的凝胶结构。除了通常用于预测凝胶形态行为的溶剂 - 溶质相互作用外，我们还观察到有迹象表明结晶度在决定FmocFF有机凝胶的机械性能和结构方面也起着重要作用。
