Department of Neurosurgery, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Vascular Neurosurgery, National Institute of Neurovascular Disease, 077160 Bucharest, Romania.
Curr Oncol. 2024 Oct 25;31(11):6659-6672. doi: 10.3390/curroncol31110491.
In this retrospective unicentric study, we analyzed the medical records of 11 patients who were surgically treated for CNS lymphoma, both primary and secondary, between 2009 and 2024. Given the rarity of CNS lymphomas and their diverse signs and symptoms based on tumoral location, our aim was to describe key aspects, such as clinical presentations and surgical management. A possible relationship between obesity and CNS lymphoma progression was investigated through an analysis of previous study findings. The literature suggests a wide spectrum of manifestations, from nausea and headaches to loss of equilibrium and speech impairment. A predominance of unsystematized balance disorders and epileptic seizures were affirmed. Notably, as emerged from our study, aphasia was a particularly interesting neurological symptom due to its rarity in the clinical features of CNSL. Other significant factors, such as tumor localization and perioperative phases, were thoroughly investigated, with the latter highlighted by an illustrative case report. Additionally, a literature review was included, comprising nine recent retrospective studies on the efficacy of surgical resection for patients diagnosed with PCNSL.
在这项回顾性单中心研究中，我们分析了 2009 年至 2024 年间 11 例经手术治疗的中枢神经系统淋巴瘤（原发性和继发性）患者的病历。鉴于中枢神经系统淋巴瘤的罕见性及其基于肿瘤位置的不同表现和症状，我们旨在描述关键方面，如临床表现和手术管理。通过分析先前的研究结果，我们研究了肥胖与中枢神经系统淋巴瘤进展之间的可能关系。文献表明，其临床表现范围广泛，从恶心和头痛到失去平衡和言语障碍。我们确认以非系统性平衡障碍和癫痫发作为主。值得注意的是，正如我们的研究所表明的，失语症是一种特别有趣的神经症状，因为它在中枢神经系统淋巴瘤的临床特征中很少见。其他重要因素，如肿瘤定位和围手术期阶段，也进行了彻底研究，后者通过一个说明性病例报告得到了强调。此外，还包括了对诊断为原发性中枢神经系统淋巴瘤患者手术切除疗效的九项最近回顾性研究的文献综述。
