Sánchez-Quintana Damián, Macías Yolanda, Nevado-Medina Jorge, Spicer Diane E, Anderson Robert H
Department of Human Anatomy and Cell Biology, Faculty of Medicine, University of Extremadura, 06006 Badajoz, Spain.
Heart Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL 33701, USA.
J Cardiovasc Dev Dis. 2024 Oct 24;11(11):340. doi: 10.3390/jcdd11110340.
Those using the mouse for the purposes of electrophysiological research presume that the morphology of the conduction axis is comparable with the human arrangement. As yet, however, to the best of our knowledge, no direct comparison has been made between the species. By comparing our extensive histological findings in the human heart with comparable serially-sectioned datasets prepared from adult murine hearts, we aimed to provide this information. When comparing the gross anatomy, we used three-dimensional datasets of neonatal mice hearts prepared using episcopic microscopy. The overall cardiac architecture is comparable, although the mouse has a persistent left superior caval vein draining via the coronary sinus. An inferior pyramidal space and an infero-septal recess are both present in the murine heart, although they are not as well developed as in the human heart. The overall arrangement of the conduction axis is similarly comparable, albeit with subtle differences reflecting the incomplete wedging of the subaortic outflow tract in the murine heart. Most significantly, the findings in both species reveal the presence of extensive superior septal pathways, which perhaps explain the finding of base-to-apex activation of the ventricular mass known to occur in the murine heart.
那些将小鼠用于电生理研究的人假定其传导轴的形态与人类的排列方式具有可比性。然而，据我们所知，目前尚未对这两个物种进行直接比较。通过将我们在人类心脏中广泛的组织学研究结果与从成年小鼠心脏制备的可比连续切片数据集进行比较，我们旨在提供这方面的信息。在比较大体解剖结构时，我们使用了通过光学显微镜制备的新生小鼠心脏的三维数据集。尽管小鼠有一条持续存在的左上腔静脉经冠状窦引流，但整体心脏结构具有可比性。小鼠心脏中存在下锥体间隙和下间隔隐窝，尽管它们不如人类心脏中发育完善。传导轴的整体排列同样具有可比性，尽管存在细微差异，反映了小鼠心脏主动脉下流出道的不完全楔入。最重要的是，两个物种的研究结果都显示存在广泛的上间隔通路，这或许可以解释在小鼠心脏中已知发生的心室质量从心底到心尖的激活现象。
