Billy A J, Crews D
J Morphol. 1986 Feb;187(2):129-42. doi: 10.1002/jmor.1051870202.
Cnemidophorus uniparens is a parthenogenetic unisexual species of lizard in which each individual develops as a female, making it a unique animal model for the study of sexual differentiation. In one study, administration of exogenous testosterone before and/or after hatching influenced the development of the gonads, the accessory reproductive ducts, the renal sex segment of the mesonephric kidney, and the femoral glands, a secondary sex character. Testosterone treatment also affected the cross-sectional area of the gonad and the proportions of cortical and medullary tissues present in the developing gonad. The oviducts and femoral glands of testosterone-treated individuals were hypertrophied; the collecting tubules of the kidney of these animals contained granules, an androgen-dependent, sexually dimorphic character in squamate reptiles. In another study, testosterone, dihydrotestosterone, or estradiol were administered to C. uniparens embryos. No treatment effects on gonadal development were detected on the day of hatching. However, estradiol, but not testosterone and dihydrotestosterone, stimulated development of the oviducts. Taken together these studies suggest that androgen aromatization may play a role in sexual differentiation in lizards.
鞭尾蜥是一种孤雌生殖的单性蜥蜴物种，每个个体都发育为雌性，这使其成为研究性别分化的独特动物模型。在一项研究中，孵化前和/或孵化后给予外源性睾酮会影响性腺、附属生殖管道、中肾的肾性节段以及股腺（一种第二性征）的发育。睾酮处理还影响性腺的横截面积以及发育中性腺中皮质和髓质组织的比例。接受睾酮处理的个体的输卵管和股腺肥大；这些动物肾脏的集合小管含有颗粒，这是有鳞目爬行动物中一种雄激素依赖性的两性异形特征。在另一项研究中，将睾酮、双氢睾酮或雌二醇施用于鞭尾蜥胚胎。在孵化当天未检测到对性腺发育的处理效果。然而，雌二醇而非睾酮和双氢睾酮刺激了输卵管的发育。综合这些研究表明，雄激素芳香化可能在蜥蜴的性别分化中起作用。
