Crews D, Traina V, Wetzel F T, Muller C
Endocrinology. 1978 Nov;103(5):1814-21. doi: 10.1210/endo-103-5-1814.
The androgen aromatization hypothesis was examined in the male lizard, Anolis carolinensis. After castration, sc silastic implants of testosterone (T) restored both challenge and courtship behavior, while dihydrotestosterone (DHT) or 17beta-estradiol (E) had no effect on male behaviors. Both T and DHT, but not E, stimulated hypertrophy and colloid production by the renal sex segment, a secondary sexual characteristic of male lizards. In two separate studies, castrates received DHT in combination with E. In each replicate, half of the castrates responded with increases in courtship behavior after hormone treatment. Epithelial cell height of the sex segment of all DHT and E-treated castrates was comparable to T- or DHT-treated castrates, but colloid production was not stimulated. These experiments indicate that in this species, treatment with T stimulates both sexual behavior and secondary sex character development, whereas treatment with E alone is without effect centrally or peripherally.
在雄性卡罗来纳安乐蜥中检验了雄激素芳香化假说。去势后，皮下硅橡胶植入睾酮（T）可恢复攻击和求偶行为，而双氢睾酮（DHT）或17β-雌二醇（E）对雄性行为无影响。T和DHT均可刺激雄性蜥蜴的第二性征——肾性节的肥大和胶体生成，但E无此作用。在两项独立研究中，去势动物接受DHT与E联合治疗。在每次重复实验中，一半去势动物在激素治疗后求偶行为增加。所有接受DHT和E治疗的去势动物的性节上皮细胞高度与接受T或DHT治疗的去势动物相当，但胶体生成未受刺激。这些实验表明，在该物种中，T治疗可刺激性行为和第二性征发育，而单独使用E在中枢或外周均无作用。
