Patra A L
J Toxicol Environ Health. 1986;17(2-3):163-74. doi: 10.1080/15287398609530813.
Silicone rubber casts of the respiratory tract were used in morphological studies of the human, baboon, rhesus monkey, dog, rabbit, guinea pig, rat, hamster, and mouse. In these studies, the trachea of the specimen was opened by tracheotomy, and silicone rubber (734 RTV) was introduced through the trachea to form nasopharyngeal and tracheobronchial casts. Measurements were made on the nasal structures, and the lungs were observed for species variation in branching pattern and number of lobes per lung. While species differences in respiratory tract anatomy are known to exist, the present study provides a focus for toxicologists when extrapolating toxicological results from one species to another.
呼吸道的硅橡胶铸型被用于人类、狒狒、恒河猴、狗、兔子、豚鼠、大鼠、仓鼠和小鼠的形态学研究。在这些研究中，通过气管切开术打开标本的气管，并将硅橡胶（734室温硫化硅橡胶）经气管注入以形成鼻咽和气管支气管铸型。对鼻腔结构进行测量，并观察肺部叶的分支模式和每侧肺叶数量的物种差异。虽然已知呼吸道解剖结构存在物种差异，但本研究为毒理学家在将毒理学结果从一个物种外推至另一个物种时提供了一个关注点。
