Early alveolar clearance in rabbits intermittently exposed to sulfuric acid mist.

During the course of 1-h/d, 5-d/wk exposure to submicrometer sulfuric acid mist at 250 micrograms/m3, rabbits were exposed to a radioactively tagged polystyrene latex tracer aerosol to assess clearance from the alveolar region during the period 2-14 d after tracer exposure. The latex was administered on d 1, 57, and 240 following the start of the H2SO4 exposures. Early alveolar clearance was found to be accelerated during the first test, and this acceleration was maintained throughout the 8-mo monitoring period.