Lill P H, Gangemi J D
J Toxicol Environ Health. 1986;17(4):347-56. doi: 10.1080/15287398609530829.
Transient suppression of splenic natural killer (NK), natural cytotoxic (NC), and peritoneal macrophage cytotoxicity was observed following a single injection of 3-methylcholanthrene (3-MC) into C3H/HeN mice. Natural killer cell activity was depressed by 30-60% 4-6 d after injection of 1.0 mg 3-MC. Levels of NK reactivity returned to normal 8 d post 3-MC injection, and no suppression of natural killing was seen when tested 6 wk after 3-MC treatment. 3-MC did not affect Propionibacterium acnes augmentation of NK cell activity when tested both 6 d and 6 wk after carcinogen injection. The results indicate that the observed suppression of naturally cytotoxic cells may not be important in allowing 3-MC-induced tumors to grow, since suppression is not long-lasting. Therefore, any effect on tumor growth mediated by a suppression of naturally cytotoxic cells would have to be exerted at the earliest stages of tumor development.
给C3H/HeN小鼠单次注射3-甲基胆蒽（3-MC）后，观察到脾脏自然杀伤（NK）细胞、自然细胞毒性（NC）细胞以及腹腔巨噬细胞的细胞毒性出现短暂抑制。注射1.0毫克3-MC后4 - 6天，自然杀伤细胞活性降低30 - 60%。3-MC注射后8天，NK反应水平恢复正常，在3-MC处理6周后进行检测时未发现自然杀伤作用受到抑制。在致癌物注射后6天和6周进行检测时，3-MC均未影响痤疮丙酸杆菌对NK细胞活性的增强作用。结果表明，所观察到的对自然细胞毒性细胞的抑制作用可能对3-MC诱导肿瘤的生长并不重要，因为这种抑制并非持久存在。因此，由自然细胞毒性细胞抑制介导的对肿瘤生长的任何影响都必须在肿瘤发展的最早阶段发挥作用。
