超越同源重组缺陷状态：解析影响晚期卵巢癌中PARP抑制剂敏感性的基因变异
Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer.
作者信息
Kjeldsen Maj K, Jørgensen Morten, Grønseth Dina Sofie B, Schønemann-Lund Martin, Nyvang Gitte-Bettina, Haslund Charlotte Aaquist, Knudsen Anja Oer, Motavaf Anne Krejbjerg, Malander Susanne, Anttila Maarit, Lindahl Gabriel, Mäenpää Johanna, Dimoula Maria, Werner Theresa L, Iversen Trine Zeeberg, Hietanen Sakari, Fokdal Lars, Dahlstrand Hanna, Bjørge Line, Birrer Michael J, Mirza Mansoor R, Rossing Maria
机构信息
Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Center for Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
出版信息
Cancer Res Commun. 2024 Dec 1;4(12):3190-3200. doi: 10.1158/2767-9764.CRC-24-0294.
The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.
PARPi在HRD阳性和阴性肿瘤中的不规则反应凸显了识别其他生物标志物的必要性。本研究探索了AOC中HRD状态以外的突变格局，最终推动未来临床实践中的精准肿瘤学发展。
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