Silva Carolina, Abrantes Ana Carolina, Fontes Ana Carolina, Dias Isabel, Domingues Rosário, Peixoto Francisco, Viegas Carlos
Department of Veterinary Sciences, School of Agricultural and Veterinary Sciences (ECAV), University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal.
Animal and Veterinary Research Center (CECAV)-AL4AnimalS, University of Trás-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
Vet Sci. 2024 Nov 19;11(11):581. doi: 10.3390/vetsci11110581.
This is a retrospective study about haematological ratios in different stages of canine periodontal disease in one single breed, more specifically the Portuguese Podengo. The aim of the study was to assess the clinical significance of five haematological ratios, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-platelet count ratio (MPV/PLT), monocyte-to-lymphocyte ratio (MLR), and platelet-to-neutrophil ratio (PNR), easily obtained through the parameters provided by the complete blood count, in the stages of gingivitis and periodontitis, compared to clinical healthy individuals. Receiver operating characteristic curves were generated to identify ideal sensitivity and specificity cut-offs for cases of gingivitis or periodontitis. Our study included 80 dogs, which comprised 24 healthy dogs, 26 diagnosed with gingivitis, and 30 with periodontitis. The median NLR was significantly lower in periodontitis than in clinical healthy dogs ( = 0.040) and in dogs with gingivitis ( = 0.037). The median PLR was significantly lower in cases of gingivitis ( = 0.020) and periodontitis ( = 0.024) than in healthy dogs. MPV/PLT and MLR did not demonstrate significant differences between any of the three groups. The median PNR was significantly lower in gingivitis than in control dogs ( = 0.019). PNR had the highest accurate results, in distinguishing between healthy individuals and those with gingivitis, with an area under the curve of 0.692 (95% CI [0.539-0.845], = 0.020). However, even this index had weak discriminatory power between the groups in the analysis. The impact of systemic inflammation generated by canine periodontal disease can thus be seen through some of these indices. However, the results obtained here demonstrate the need for complementarity with other methods to diagnose canine periodontal disease and reinforce the need for additional studies with more markers of systemic inflammatory response.
这是一项关于单一犬种（即葡萄牙波登可犬）不同阶段牙周病血液学指标的回顾性研究。该研究的目的是评估五个血液学指标的临床意义，即中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）、平均血小板体积与血小板计数比率（MPV/PLT）、单核细胞与淋巴细胞比率（MLR）以及血小板与中性粒细胞比率（PNR），这些指标可通过全血细胞计数提供的参数轻松获得，用于比较牙龈炎和牙周炎阶段与临床健康个体的差异。生成了受试者工作特征曲线，以确定牙龈炎或牙周炎病例的理想敏感性和特异性临界值。我们的研究包括80只狗，其中24只为健康犬，26只被诊断为牙龈炎，30只患有牙周炎。牙周炎组的NLR中位数显著低于临床健康犬（P = 0.040）和牙龈炎犬（P = 0.037）。牙龈炎病例（P = 0.020）和牙周炎病例（P = 0.024）的PLR中位数显著低于健康犬。MPV/PLT和MLR在三组之间均未显示出显著差异。牙龈炎组的PNR中位数显著低于对照犬（P = 0.019）。在区分健康个体和牙龈炎个体方面，PNR的准确结果最高，曲线下面积为0.692（95%CI[0.539 - 0.845]，P = 0.020）。然而，即使该指标在分析中对各组之间的区分能力也较弱。因此，犬牙周病产生的全身炎症影响可通过其中一些指标体现出来。然而，此处获得的结果表明需要与其他方法互补以诊断犬牙周病，并加强对更多全身炎症反应标志物进行额外研究的必要性。
