Rodean Ioana-Patricia, Halațiu Vasile-Bogdan, Popa Teodora Maria, Blîndu Emanuel, Mihăilă Theofana, Țolescu Constantin, Modiga Andrei, Benedek Imre, Benedek Theodora
George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania.
Int J Mol Sci. 2025 May 3;26(9):4360. doi: 10.3390/ijms26094360.
(1) The link between periodontal disease (PD) and acute coronary syndromes (ACSs) is predominantly attributed to the atherosclerotic process, mediated by systemic inflammation. However, the correlation between the severity of PD, characterized by the presence of periodontal pathogens, and systemic inflammation in patients with ACS remains inadequately clarified. (2) This study aims to assess the association between the severity of PD and systemic inflammatory biomarkers, along with lipid profiles, in patients with ACS. (3) In total, 42 patients with ACS and concomitant PD were divided into two groups based on the presence of periodontal pathogens belonging to the red or red-orange complexes. Group 1-29 patients displayed pathogens from the red complex (RC) and group 2-13 patients displayed pathogens from the red-orange complex (ROC). All participants underwent a comprehensive dental examination, including DNA sampling from the periodontal pockets for pathogen detection. Systemic inflammation was evaluated alongside assessments of lipid profiles. (4) Inflammatory markers were more pronounced in the RC group compared with the ROC group. Moreover, patients in the RC group showed significantly higher monocyte-to-lymphocyte ratios (0.41 ± 0.20 vs. 0.28 ± 0.12; = 0.002), platelet-to-lymphocyte ratios (139.50 ± 33.85 vs. 100.90 ± 8.84; = 0.02), serum C-reactive protein levels (9.34 ± 1.08 mg/L vs. 5.46 ± 1.03 mg/L; = 0.03), and serum uric acid levels (6.9 ± 0.49 mg/dL vs. 5.4 ± 0.26 mg/dL; = 0.006). Concerning lipid profiles, the RC group exhibited significantly higher low-density lipoprotein cholesterol (LDL) levels (169.60 ± 12.63 mg/dL vs. 106.70 ± 9.34 mg/dL; = 0.0007) and significantly lower high-density lipoprotein cholesterol (HDL) levels (29.29 ± 3.50 mg/dL vs. 39.56 ± 2.07 mg/dL; = 0.002). (5) The severity of PD, indicated by the concomitant presence of pathogens from the red and orange complexes, is associated with an unfavorable lipid profile and elevated inflammatory biomarkers. These findings highlight the potential importance of periodontal intervention in the prevention of ACS.
(1) 牙周疾病（PD）与急性冠脉综合征（ACSs）之间的联系主要归因于由全身炎症介导的动脉粥样硬化过程。然而，以牙周病原体的存在为特征的PD严重程度与ACS患者全身炎症之间的相关性仍未得到充分阐明。(2) 本研究旨在评估ACS患者中PD严重程度与全身炎症生物标志物以及血脂谱之间的关联。(3) 总共42例患有ACS并伴有PD的患者根据是否存在属于红色或红橙色复合体的牙周病原体被分为两组。第1组 - 29例患者显示来自红色复合体（RC）的病原体，第2组 - 13例患者显示来自红橙色复合体（ROC）的病原体。所有参与者均接受了全面的牙科检查，包括从牙周袋采集DNA样本以检测病原体。同时评估全身炎症和血脂谱。(4) 与ROC组相比，RC组的炎症标志物更为明显。此外，RC组患者的单核细胞与淋巴细胞比率显著更高（0.41±0.20对0.28±0.12；P = 0.002），血小板与淋巴细胞比率（139.50±33.85对100.90±8.84；P = 0.02），血清C反应蛋白水平（9.34±1.08mg/L对5.46±1.03mg/L；P = 0.03），以及血清尿酸水平（6.9±0.49mg/dL对5.4±0.26mg/dL；P = 0.006）。关于血脂谱，RC组的低密度脂蛋白胆固醇（LDL）水平显著更高（169.60±12.63mg/dL对106.70±9.34mg/dL；P = 0.0007），高密度脂蛋白胆固醇（HDL）水平显著更低（29.29±3.50mg/dL对39.56±2.07mg/dL；P = 0.002）。(5) 由红色和橙色复合体中的病原体同时存在所表明的PD严重程度与不良血脂谱和炎症生物标志物升高有关。这些发现突出了牙周干预在预防ACS中的潜在重要性。
