Development. 2024 Nov 15;151(22). doi: 10.1242/dev.204484. Epub 2024 Nov 26.
Previous work has suggested that problems with placental development might lead to congenital heart defects. However, little is known about the mechanisms that might underpin this relationship between the placenta and the heart. A new paper in Development leverages conditional mouse knockouts to explore this link in detail. To learn more about the story behind the paper, we caught up with first author Wenli Fan and corresponding author Zhongzhou Yang, a Professor at Nanjing University Medical School, China.
先前的研究表明,胎盘发育问题可能导致先天性心脏缺陷。然而,人们对于胎盘和心脏之间这种关系的潜在机制知之甚少。发育领域的一篇新论文利用条件性小鼠敲除来详细探索这一联系。为了更多地了解这篇论文背后的故事,我们采访了第一作者范文丽和通讯作者、中国南京大学医学院教授杨中州。