Ahuja Dhruv, Singh Ashish Kumar, Batra Puneet
Department of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, FaridabadManav Rachna International Institute of Research and Studies (MRIIRS), Haryana, India.
Department of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, FaridabadManav Rachna International Institute of Research and Studies (MRIIRS), Haryana, India.
Int Orthod. 2025 Mar;23(1):100955. doi: 10.1016/j.ortho.2024.100955. Epub 2024 Nov 25.
This study aims to evaluate the efficacy of coated nanoparticles within orthodontic appliances as a novel strategy to enhance their antibacterial properties.
A systematic search for relevant articles published between 2013 and March 2024 was conducted across electronic databases including PubMed, Scopus, Web of Science, and EBSCOhost. Studies meeting pre-defined eligibility criteria were included and assessed for methodological quality. Data on the antibacterial activity of coated nanoparticles on orthodontic appliances was extracted from included studies.
A range of antimicrobial agents, including metallic nanoparticles (silver, titanium dioxide, silver-platinum alloy, zinc oxide, copper oxide), and others like chitosan, quaternary ammonium-modified gold nanoclusters, titanium nitride doped with calcium phosphate, and graphene oxide, have been explored for incorporation into orthodontic materials. Studies have shown a significant boost in the antibacterial capacity of these materials compared to controls, suggesting promise for improved oral hygiene during orthodontic treatment.
It can be concluded that incorporating nanoparticles into orthodontic appliances holds promise for enhancing their antibacterial properties. However, the studies displayed significant heterogeneity therefore, further research with standardized protocols for factors like nanoparticle size, concentration, and incorporation techniques across various orthodontic materials is crucial to guide future clinical applications.
CRD42024521326.
本研究旨在评估正畸矫治器中包覆纳米颗粒作为增强其抗菌性能的新策略的疗效。
在包括PubMed、Scopus、Web of Science和EBSCOhost在内的电子数据库中，对2013年至2024年3月发表的相关文章进行系统检索。纳入符合预定义纳入标准的研究，并评估其方法学质量。从纳入研究中提取关于包覆纳米颗粒对正畸矫治器抗菌活性的数据。
已探索了一系列抗菌剂，包括金属纳米颗粒（银、二氧化钛、银 - 铂合金、氧化锌、氧化铜）以及其他如壳聚糖、季铵改性金纳米簇、磷酸钙掺杂的氮化钛和氧化石墨烯等，用于掺入正畸材料中。研究表明，与对照组相比，这些材料的抗菌能力有显著提高，这表明在正畸治疗期间改善口腔卫生方面具有前景。
可以得出结论，将纳米颗粒掺入正畸矫治器有望增强其抗菌性能。然而，研究显示出显著的异质性，因此，针对纳米颗粒大小、浓度和掺入技术等因素，在各种正畸材料中采用标准化方案进行进一步研究对于指导未来的临床应用至关重要。
PROSPERO注册编号：CRD42024521326。
