School of Psychology, Shenzhen University, Shenzhen, China.
Tech X Academy, Shenzhen Polytechnic University, Shenzhen, China.
Commun Biol. 2024 Nov 26;7(1):1573. doi: 10.1038/s42003-024-07129-x.
Previous studies suggest that pain perception is greatly shaped by anticipation, with M1 and DLPFC involved in this process. We hypothesized that high-frequency rTMS targeting these regions could alter pain anticipation and thereby reduce pain perception. In a double-blind, sham-controlled study, healthy participants received 10 Hz rTMS to M1, DLPFC, or a sham treatment. Assessments were conducted before, immediately after, and 60 min after stimulation, including laser-evoked potentials, pain ratings, and anticipatory EEG. M1-rTMS immediately reduced laser-evoked P2 amplitude, increased sensorimotor high-frequency α-oscillation power, and accelerated peak alpha frequency in the midfrontal region during pain anticipation. In contrast, DLPFC-rTMS reduced the N2-P2 complex and pain ratings 60 min post-stimulation, an effect associated with prolonged microstate C duration during pain anticipation-a microstate linked to default mode network activity. Thus, M1-rTMS immediately modulates anticipatory α-oscillations and laser-evoked potentials, while DLPFC-rTMS induces delayed analgesic effects partially by modulating default mode network activity.
先前的研究表明，疼痛感知受预期的影响极大，其中 M1 和 DLPFC 区域参与了这一过程。我们假设针对这些区域的高频 rTMS 刺激可能会改变疼痛预期，从而降低疼痛感知。在一项双盲、假刺激对照研究中，健康参与者接受了 10Hz rTMS 对 M1、DLPFC 或假刺激的刺激。评估在刺激前、刺激后即刻和 60 分钟后进行，包括激光诱发的电位、疼痛评分和预期的 EEG。M1-rTMS 即刻降低了激光诱发的 P2 振幅，增加了感觉运动高频 α 振荡功率，并加速了中额区疼痛预期期间的峰值 α 频率。相比之下，DLPFC-rTMS 在刺激后 60 分钟降低了 N2-P2 复合体和疼痛评分，这一效应与疼痛预期期间微状态 C 持续时间延长有关，微状态与默认模式网络活动有关。因此，M1-rTMS 即刻调节预期的 α 振荡和激光诱发的电位，而 DLPFC-rTMS 通过调节默认模式网络活动诱导延迟的镇痛效应。
