代谢综合征与年轻人慢性阻塞性肺疾病发展的关系：一项全国性队列研究。

Association between metabolic syndrome and chronic obstructive pulmonary disease development in young individuals: a nationwide cohort study.

机构信息

Division of Pulmonology and Allergy, Department of Internal Medicine, Chungnam National University, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.

Department of Biomedicine and Health Science, The Catholic University of Korea, Seoul, Republic of Korea.

出版信息

Respir Res. 2024 Nov 26;25(1):414. doi: 10.1186/s12931-024-03038-z.

DOI:10.1186/s12931-024-03038-z

PMID:39593103

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11590416/

Abstract

BACKGROUND

The association between metabolic syndrome (MetS) and chronic obstructive pulmonary disease (COPD) has not been studied well, particularly in young individuals. We investigated the risk of COPD development in young individuals based on MetS and its components.

METHODS

We used the Korean National Health Information Database to identify 6,891,400 individuals aged 20-39 years who participated in the national health check-up service between 2009 and 2012. Then, we identified individuals with MetS and investigated COPD development based on health insurance claims. Cox proportional hazard regression models were used to calculate the adjusted hazard ratio (aHR) for the risk of COPD development.

RESULTS

During a mean follow-up period of 8.35 years, 13,784 individuals were newly diagnosed with COPD. MetS was associated with an increased risk of COPD (aHR, 1.18; 95% confidence interval [CI], 1.11-1.24). Among the MetS components, except for hyperglycemia, abdominal obesity (aHR, 1.27; 95% CI, 1.19-1.34), hypertension (aHR, 1.05; 95% CI, 1.01-1.10), hypertriglyceridemia (aHR, 1.11; 95% CI, 1.07-1.16), and low high-density lipoprotein cholesterol levels (aHR, 1.16; 95% CI, 1.11-1.22) were significantly associated with COPD development. A higher number of MetS components correlated with an increased risk of COPD development, with the highest risk observed when all five MetS components were present (aHR, 1.55; 95% CI, 1.28-1.87).

CONCLUSION

MetS was associated with COPD development in young individuals. The risk of COPD development increased along with the increasing number of MetS components. These findings suggest that careful monitoring for COPD development is necessary in young individuals with MetS, especially those with multiple components of MetS.

摘要

背景

代谢综合征（MetS）与慢性阻塞性肺疾病（COPD）之间的关联尚未得到很好的研究，尤其是在年轻人中。我们调查了基于 MetS 及其组成部分的年轻人患 COPD 的风险。

方法

我们使用韩国国家健康信息数据库，确定了 6891400 名年龄在 20-39 岁之间的个体，他们在 2009 年至 2012 年期间参加了国家健康检查服务。然后，我们确定了患有 MetS 的个体，并根据健康保险索赔调查了 COPD 的发展情况。使用 Cox 比例风险回归模型计算 COPD 发展风险的调整后的危险比（aHR）。

结果

在平均 8.35 年的随访期间，有 13784 人被新诊断为 COPD。MetS 与 COPD 的发病风险增加相关（aHR，1.18；95%置信区间 [CI]，1.11-1.24）。在 MetS 成分中，除了高血糖外，腹型肥胖（aHR，1.27；95%CI，1.19-1.34）、高血压（aHR，1.05；95%CI，1.01-1.10）、高三酰甘油血症（aHR，1.11；95%CI，1.07-1.16）和低高密度脂蛋白胆固醇水平（aHR，1.16；95%CI，1.11-1.22）与 COPD 发病显著相关。患有更多 MetS 成分与 COPD 发病风险增加相关，当存在所有五个 MetS 成分时，风险最高（aHR，1.55；95%CI，1.28-1.87）。