Rault Christophe C S, Heraud Quentin, Ansquer Solène, Ragot Stéphanie, Kostencovska Angela, Thille Arnaud W, Stancu Alexandra, Saulnier Pierre-Jean, Drouot Xavier
Faculty of Medicine and Pharmacy, INSERM, Clinical Investigation Center 1402, Research Team Is-Alive, University of Poitiers, Poitiers, France.
Department of Functional Explorations, Respiratory and Exercise Physiology, Poitiers University Hospital, Poitiers, France.
J Clin Neurophysiol. 2024 Nov 27;42(5):457-465. doi: 10.1097/WNP.0000000000001134.
Sleep deprivation (SD) reduces time to task failure during endurance exercises. The aim of our work was to study the effect of acute SD on the endurance of a skeletal hand muscle and to investigate cortical motor drive to muscle and perception of effort.
Origin of the early exhaustion after SD might be insufficient cortical motor drive to muscle or motor inhibition because of excessive perception of effort. The supplementary motor area, the medial part of the premotor cortex, links the motor and sensory cortexes, prepares for voluntary movements, and may play a central role in the pathophysiology of impaired muscle endurance after SD. Supplementary motor area can be noninvasively assessed by electromyogram measuring amplitude of premotor potentials before hand movements. We investigated the effect of SD on muscle endurance in healthy volunteers performing moderate hand exercise by monitoring supplementary motor area activation and muscle afferents. Two sessions were performed, in random order, one after a normal sleep night and the other after a sleepless night.
Twenty healthy young men were included in this study. Sleep deprivation reduced time to task failure by 11%. Supplementary motor area activation was altered throughout the task and effort perception was increased.
Our results suggest that SD reduces skeletal muscle endurance by increasing the effects of muscle afferents on the supplementary motor area. Sleep alterations frequently reported in chronic diseases might reduce patients' capacity to achieve the low-intensity motor exercises required in everyday life. Our results should lead to the search for sleep disorders in patients with chronic pathology.
睡眠剥夺（SD）可缩短耐力运动中任务失败的时间。我们研究的目的是探讨急性睡眠剥夺对骨骼肌手部肌肉耐力的影响，并研究皮层对肌肉的运动驱动以及努力感知情况。
睡眠剥夺后早期疲劳的原因可能是皮层对肌肉的运动驱动不足或由于过度的努力感知导致的运动抑制。辅助运动区，即运动前皮层的内侧部分，连接运动皮层和感觉皮层，为自主运动做准备，并且可能在睡眠剥夺后肌肉耐力受损的病理生理学中起核心作用。辅助运动区可通过在手部运动前测量运动前电位的幅度的肌电图进行无创评估。我们通过监测辅助运动区激活和肌肉传入神经，研究了睡眠剥夺对进行适度手部运动的健康志愿者肌肉耐力的影响。随机进行了两次实验，一次在正常睡眠一晚后进行，另一次在无睡眠一晚后进行。
本研究纳入了20名健康年轻男性。睡眠剥夺使任务失败时间缩短了11%。在整个任务过程中，辅助运动区的激活发生了改变，努力感知增加。
我们的结果表明，睡眠剥夺通过增加肌肉传入神经对辅助运动区的影响来降低骨骼肌耐力。慢性病中经常报告的睡眠改变可能会降低患者进行日常生活所需的低强度运动的能力。我们的结果应促使人们在慢性病患者中寻找睡眠障碍。
