Department of Kinesiology, University of New Hampshire, Durham, NH, USA; Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA.
Department of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, KS, USA; Department of Physical Therapy, California State University, Fresno, CA, USA.
J Bodyw Mov Ther. 2024 Oct;40:1002-1007. doi: 10.1016/j.jbmt.2024.07.025. Epub 2024 Jul 9.
Neuroinflammation contributes to degeneration of neurons in people with Parkinson's disease (PD). The concentrations of inflammatory cytokines, IL-1β, IL-6, and TNF-α, are often increased in people with PD and are associated with various non-motor symptoms. Qigong exercise is a mind-body practice which has been used as a rehabilitation intervention for people with PD. A previous study showed a strong association between sleep quality and inflammatory status. This study investigated the effect of Qigong on inflammatory status in people with PD and explored potential relationships between inflammatory status and sleep quality in this population.
The study was a randomized controlled trial. A total of 17 participants completed the 12-week intervention (Qigong (n = 8), sham Qigong (n = 9)). Questionnaires were utilized to assess non-motor symptoms, including sleep quality. Inflammatory cytokines were measured by a high sensitivity antibody-based multiplex assay.
After the 12-week intervention, a decreasing trend in the concentrations of IL-1β and IL-6 was found in the Qigong group. Moderate to strong correlations were found between changes in IL-1β concentrations and sleep quality.
Inflammation is an important aspect of PD. This study explored the inflammatory status after a mind-body exercise. Further studies need to extend our findings to confirm the effect of Qigong in people with PD.
神经炎症会导致帕金森病（PD）患者神经元退化。炎症细胞因子（IL-1β、IL-6 和 TNF-α）的浓度在 PD 患者中通常会升高，并与各种非运动症状有关。气功是一种身心练习，已被用作 PD 患者的康复干预措施。先前的一项研究表明，睡眠质量与炎症状态之间存在很强的关联。本研究调查了气功对 PD 患者炎症状态的影响，并探讨了该人群中炎症状态与睡眠质量之间的潜在关系。
这是一项随机对照试验。共有 17 名参与者完成了 12 周的干预（气功组（n=8），假气功组（n=9））。问卷调查用于评估非运动症状，包括睡眠质量。炎症细胞因子通过高灵敏度抗体基多重检测法进行测量。
在 12 周的干预后，气功组中 IL-1β 和 IL-6 的浓度呈下降趋势。IL-1β 浓度的变化与睡眠质量之间存在中度到高度的相关性。
炎症是 PD 的一个重要方面。本研究探讨了身心练习后的炎症状态。需要进一步的研究来扩展我们的发现，以确认气功对 PD 患者的影响。
