Departments of Social Work and Social Administration, The University of Hong Kong, Hong Kong Special Administrative Region; Centre on Behavioral Health, Faculty of Social Sciences, The University of Hong Kong, Hong Kong Special Administrative Region.
Departments of Social Work and Social Administration, The University of Hong Kong, Hong Kong Special Administrative Region; Centre on Behavioral Health, Faculty of Social Sciences, The University of Hong Kong, Hong Kong Special Administrative Region.
Brain Behav Immun. 2022 Jan;99:166-176. doi: 10.1016/j.bbi.2021.09.022. Epub 2021 Oct 8.
Depressed people are prone to sleep disturbance, which may in return perpetuate the depression. Both depression and sleep disturbance influence proinflammatory cytokines interleukin (IL) 6 and 1β. Thus interventions for depression should consider the effect on sleep disturbance, and vice versa. Integrative Body-Mind-Spirit (IBMS) and Qigong interventions have been applied in a wide range of health and mental health conditions, including depression and sleep disturbance. This study aimed to evaluate the effect of these two mind-body therapies for persons with both depressive symptoms and sleep disturbance. A three-arm randomized controlled trial was conducted among 281 participants, who were randomly assigned to either IBMS, Qigong or wait list control group. Participants in IBMS and Qigong groups received eight weekly sessions of intervention. Outcome measures were plasma concentrations of IL-6 and IL-1β, and a questionnaire containing Pittsburgh Sleep Quality Index, Center for Epidemiologic Studies Depression Scale, Somatic Symptom Inventory, Perceived Stress Scale and Body-Mind-Spirit Holistic Well-being Scale. Outcomes were assessed at baseline (T0), immediate post-intervention (T1) and at three-months post-intervention (T2). Besides intervention efficacy analysis, path analysis was performed to explore the relations among perceived stress, depression, sleep disturbance, and IL-6 and IL-1β values. The study found both IBMS and Qigong reduced depression, sleep disturbance, painful and painless somatic symptoms, IL-6 and IL-1β levels, and increased holistic well-being. The effect sizes of IBMS and Qigong, mostly in the medium magnitude range, were approximatively equivalent. Path analysis models revealed a predictive role of perceived stress in depression and sleep disturbance, a bidirectional relationship between depression and sleep disturbance, and significant influence of depression and sleep disturbance on IL-6 and IL-1β. Compared with control, the findings support the efficacy of IBMS and Qigong interventions in relieving depression and sleep disturbance, and in reducing IL-6 and IL-1β levels.
抑郁的人容易出现睡眠障碍，而睡眠障碍又可能反过来使抑郁持续存在。抑郁和睡眠障碍都会影响促炎细胞因子白细胞介素 (IL) 6 和 1β。因此，针对抑郁的干预措施应该考虑对睡眠障碍的影响，反之亦然。身心整合 (IBMS) 和气功干预已广泛应用于各种健康和心理健康状况，包括抑郁和睡眠障碍。本研究旨在评估这两种身心疗法对同时存在抑郁症状和睡眠障碍的人的效果。一项三臂随机对照试验在 281 名参与者中进行，他们被随机分配到 IBMS 组、气功组或等待名单对照组。IBMS 和气功组的参与者接受了八周的干预。结局指标为血浆白细胞介素-6 (IL-6) 和白细胞介素-1β (IL-1β) 浓度，以及包含匹兹堡睡眠质量指数、流行病学研究抑郁量表、躯体症状清单、感知压力量表和身心整体幸福感量表的问卷。在基线 (T0)、干预即刻后 (T1) 和干预后三个月 (T2) 评估结局。除了干预效果分析外，还进行了路径分析，以探讨感知压力、抑郁、睡眠障碍与 IL-6 和 IL-1β 值之间的关系。研究发现，IBMS 和气功都能降低抑郁、睡眠障碍、疼痛和无痛躯体症状、IL-6 和 IL-1β 水平，并提高整体幸福感。IBMS 和气功的效果大小，主要在中等程度范围内，大致相当。路径分析模型表明，感知压力在抑郁和睡眠障碍中具有预测作用，抑郁和睡眠障碍之间存在双向关系，抑郁和睡眠障碍对 IL-6 和 IL-1β 有显著影响。与对照组相比，这些发现支持 IBMS 和气功干预缓解抑郁和睡眠障碍、降低 IL-6 和 IL-1β 水平的疗效。
