Li Yuan, Wang Kai, Li Chunmei
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Antioxidants (Basel). 2024 Nov 10;13(11):1375. doi: 10.3390/antiox13111375.
The intensive broiler farming model has accelerated the development of the poultry farming industry. However, it has also inevitably brought about many stressors that lead to oxidative stress in the organism. The intestine is the leading site of nutrient digestion, absorption, and metabolism, as well as a secretory and immune organ. Oxidative stress in animal production can harm the intestine, potentially leading to significant losses for the farming industry. Under conditions of oxidative stress, many free radicals are produced in the animal's body, attacking the intestinal mucosal tissues and destroying the barrier integrity of the intestinal tract, leading to disease. Recently, herbs have been shown to have a favorable safety profile and promising application in improving intestinal oxidative stress in poultry. Therefore, future in-depth studies on the specific mechanisms of herbs and their extracts for treating intestinal oxidative stress can provide a theoretical basis for the clinical application of herbs and new therapeutic options for intestinal oxidative stress injury during poultry farming. This review focuses on the causes and hazards of oxidative stress in the intestinal tract of poultry, and on herbs and their extracts with therapeutic potential, to provide a reference for developing and applying new antioxidants.
集约化肉鸡养殖模式加速了家禽养殖业的发展。然而,它也不可避免地带来了许多应激源,导致机体产生氧化应激。肠道是营养物质消化、吸收和代谢的主要场所,也是一个分泌和免疫器官。动物生产中的氧化应激会损害肠道,可能给养殖业带来重大损失。在氧化应激条件下,动物体内会产生许多自由基,攻击肠道黏膜组织,破坏肠道屏障完整性,导致疾病。近年来,草药已被证明具有良好的安全性,在改善家禽肠道氧化应激方面具有广阔的应用前景。因此,未来对草药及其提取物治疗肠道氧化应激的具体机制进行深入研究,可为草药的临床应用提供理论依据,并为家禽养殖过程中肠道氧化应激损伤提供新的治疗选择。本综述重点关注家禽肠道氧化应激的原因和危害,以及具有治疗潜力的草药及其提取物,为开发和应用新型抗氧化剂提供参考。