Claria Benjamín, Espinosa Alejandra, Rodríguez Alicia, Dovale-Rosabal Gretel, Bucarey José Luis, Pando María Elsa, Romero Nalda, Reinoso Francisca, Sánchez Camila, Valenzuela Rodrigo, Ribeiro Carolina H, Aubourg Santiago P
Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, Dr. Carlos Lorca Tobar 964, University of Chile, Santiago 8380494, Chile.
Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago 8380000, Chile.
Antioxidants (Basel). 2024 Nov 13;13(11):1384. doi: 10.3390/antiox13111384.
This study evaluated the effects of cold-pressed maqui ( (Mol.) Stuntz) seed oil (MO) on liver metabolism and biochemical markers in a high-fat diet (HFD) murine model. In it, the fatty acid profile, tocopherol and tocotrienol contents, and antioxidant capacity of MO were analyzed. Male C57BL/6 mice were divided into four groups (i.e., a, b, c, and d groups) and supplemented for 12 weeks according to the following distribution: (a) control diet (CD)-sunflower oil (SO), (b) CD+MO, (c) HFD+SO, and (d) HFD+MO. Total body and organ weights, serum markers, and liver fat infiltration were assessed. MO contained 32.31% oleic acid, 46.41% linoleic acid, and 10.83% α-linolenic acid; additionally, α- and γ-tocopherol levels were 339.09 ± 5.15 and 135.52 ± 38.03 mg/kg, respectively, while β-, δ-tocopherol, and α-tocotrienol were present in trace amounts and the antioxidant capacity measured was 6.66 ± 0.19 μmol Trolox equivalent/g. MO supplementation significantly reduced the visceral fat (0.76 ± 0.06 g vs. 1.32 ± 0.04 g) and GPT (glutamate pyruvate transaminase) levels (71.8 ± 5.0 vs. 35.2 ± 2.6 U/L), and the liver fat infiltration score (6 vs. 3) in the HFD+MO group compared to HFD+SO. It is suggested that MO may effectively prevent fatty liver disease, warranting further research on its potential benefits for human health.
本研究在高脂饮食（HFD）小鼠模型中评估了冷榨的智利酒果（(Mol.) Stuntz）籽油（MO）对肝脏代谢和生化指标的影响。分析了MO的脂肪酸组成、生育酚和生育三烯酚含量以及抗氧化能力。将雄性C57BL/6小鼠分为四组（即a、b、c和d组），并按以下分配方式补充12周：（a）对照饮食（CD）-向日葵油（SO），（b）CD+MO，（c）HFD+SO，（d）HFD+MO。评估了总体重和器官重量、血清指标以及肝脏脂肪浸润情况。MO含有32.31%的油酸、46.41%的亚油酸和10.83%的α-亚麻酸；此外，α-和γ-生育酚水平分别为339.09±5.15和135.52±38.03 mg/kg，而β-、δ-生育酚和α-生育三烯酚含量微量，测得的抗氧化能力为6.66±0.19 μmol Trolox当量/g。与HFD+SO组相比，补充MO显著降低了HFD+MO组的内脏脂肪（0.76±0.06 g对1.32±0.04 g）和GPT（谷丙转氨酶）水平（71.8±5.0对35.2±2.6 U/L）以及肝脏脂肪浸润评分（6对3）。提示MO可能有效预防脂肪肝疾病，有必要进一步研究其对人类健康的潜在益处。
