Li Yang, Fan Huihui, Wei Wei, Zhu Hanyu, Wang Haifeng, Lyu Dayao, Zhang Zengrui, Tan Ying
Department of Neurology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, People's Republic of China.
Department of Ultrasound, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, People's Republic of China.
Risk Manag Healthc Policy. 2024 Sep 7;17:2169-2179. doi: 10.2147/RMHP.S469725. eCollection 2024.
The primary clinical manifestation of venous thrombosis is discomfort in the lower extremities. Some early Parkinson's disease (PD) patients feel discomfort in the lower limbs. Venous thrombosis can risk lives by causing pulmonary embolism. This study examines the incidence of DVT in early PD patients and its correlation with different clinical and lab features.
A cross-sectional study was conducted on 117 patients with early-stage PD. Ultrasonography was employed to detect the presence of DVT. Factors such as age, gender, body mass index, lifestyle habits (smoking and drinking), medical history (hypertension, diabetes, atrial fibrillation, and tumor), and other lab tests linked to thrombosis were analyzed.
In 117 patients, 11 (9.4%) had DVT, while 106 (90.6%) did not. There were no significant differences in gender, BMI, habits, medical history, or other thrombosis-related tests between both groups. However, DVT patients were older with higher d-dimer levels. They also showed an increased right substantia nigra ultrasound echo area, higher HY grades, higher UPDRS 3 scores, less improvement in UPDRS 3 scores and levodopa response.
The primary risk factors for lower extremity venous thrombosis were found to be age, d-dimer levels, and low-dose levodopa. Therefore, for elderly patients with early-stage PD, it is crucial to conduct d-dimer and lower extremity vascular ultrasound tests. The prevention of venous thrombosis in the lower extremities of early PD patients is of utmost importance.
静脉血栓形成的主要临床表现为下肢不适。一些早期帕金森病（PD）患者会感到下肢不适。静脉血栓形成可因导致肺栓塞而危及生命。本研究调查早期PD患者深静脉血栓形成（DVT）的发生率及其与不同临床和实验室特征的相关性。
对117例早期PD患者进行横断面研究。采用超声检查来检测DVT的存在。分析了年龄、性别、体重指数、生活习惯（吸烟和饮酒）、病史（高血压、糖尿病、心房颤动和肿瘤）以及其他与血栓形成相关的实验室检查等因素。
117例患者中，11例（9.4%）发生DVT，106例（90.6%）未发生。两组在性别、体重指数、习惯、病史或其他与血栓形成相关的检查方面无显著差异。然而，DVT患者年龄较大，D-二聚体水平较高。他们还表现出右侧黑质超声回声面积增加、Hoehn-Yahr（HY）分级较高、统一帕金森病评定量表（UPDRS）Ⅲ评分较高、UPDRSⅢ评分和左旋多巴反应改善较少。
发现下肢静脉血栓形成的主要危险因素为年龄、D-二聚体水平和低剂量左旋多巴。因此，对于早期PD老年患者，进行D-二聚体和下肢血管超声检查至关重要。早期PD患者下肢静脉血栓形成的预防至关重要。
