Kuo Yang-Che, Ko Hung-Ju, Yu Lo-Yip, Shih Shou-Chuan, Wang Horng-Yuan, Lin Ying-Chun, Hu Kuang-Chun
Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei 104217, Taiwan.
Healthy Evaluation Center, MacKay Memorial Hospital, Taipei 104217, Taiwan.
Cancers (Basel). 2024 Nov 20;16(22):3881. doi: 10.3390/cancers16223881.
The connection between microbial infections and tumor formation is notably exemplified by and its association with gastric cancer (GC) and colorectal cancer (CRC). While early studies hinted at a link between and colorectal neoplasms, comprehensive retrospective cohort studies were lacking. Recent research indicates that individuals treated for infection experience a significant reduction in both CRC incidence and mortality, suggesting a potential role of this infection in malignancy development. Globally, prevalence varies, with higher rates in developing countries (80-90%) compared to developed nations (20-50%). This infection is linked to chronic gastritis, peptic ulcers, and GC, highlighting the importance of understanding its epidemiology for public health interventions. significantly increases the risk of non-cardia GC. Some meta-analyses have shown a 1.49-fold increased risk for colorectal adenomas and a 1.70-fold increase for CRC in infected individuals. Additionally, eradication may lower the CRC risk, although the relationship is still being debated. Although eradication therapy shows promise in reducing GC incidence, concerns about antibiotic resistance pose treatment challenges. The role of in colorectal tumors remains contentious, with some studies indicating an increased risk of colorectal adenoma, while others find minimal association. Future research should investigate the causal mechanisms between infection and colorectal neoplasia, including factors like diabetes, to better understand its role in tumor formation and support widespread eradication efforts to prevent both gastric and colorectal cancers.
微生物感染与肿瘤形成之间的联系在……及其与胃癌（GC）和结直肠癌（CRC）的关联中得到了显著体现。虽然早期研究暗示了……与结直肠肿瘤之间的联系，但缺乏全面的回顾性队列研究。最近的研究表明，接受……感染治疗的个体结直肠癌发病率和死亡率均显著降低，这表明这种感染在恶性肿瘤发展中可能发挥作用。在全球范围内，……的患病率各不相同，发展中国家（80 - 90%）的患病率高于发达国家（20 - 50%）。这种感染与慢性胃炎、消化性溃疡和胃癌有关，凸显了了解其流行病学对于公共卫生干预的重要性。……显著增加了非贲门胃癌的风险。一些荟萃分析表明，感染个体患结直肠腺瘤的风险增加1.49倍，患结直肠癌的风险增加1.70倍。此外，根除……可能会降低结直肠癌风险，尽管这种关系仍在争论中。虽然根除治疗在降低胃癌发病率方面显示出前景，但对抗生素耐药性的担忧带来了治疗挑战。……在结直肠肿瘤中的作用仍存在争议，一些研究表明结直肠腺瘤风险增加，而另一些研究则发现关联极小。未来的研究应调查……感染与结直肠肿瘤形成之间的因果机制，并将糖尿病等因素考虑在内，以更好地了解其在肿瘤形成中的作用，并支持广泛的根除努力以预防胃癌和结直肠癌。
