Göbel U, von Kries R, Bewersdorff S, Henninghausen B, Schmidt E
Klin Padiatr. 1986 Jan-Feb;198(1):13-6. doi: 10.1055/s-2008-1026844.
Intracranial bleeding due to vitamin K deficiency in infants without prior symptoms of disease has been reported. All of these children were fully breastfed. To evaluate a potential deficit of vitamin K dependent coagulation factors in fully breastfed infants we determined the prothrombin clotting times in healthy babies on the 5th day (n = 204) and in the 5th week of life and correlated the results to the feeding. On the fifth day of life prothrombin coagulation times in fully breastfed infants were significantly longer than in babies receiving formula exclusively or additionally. Vitamin K supply in fully breastfed neonates should therefore be reinvestigated. In the 5th week of life, however, there was no difference in prothrombin coagulation times between fully breastfed infants and infants with exclusive or supplementary formula feeding.
已有报道称，在没有疾病前期症状的婴儿中，会出现因维生素K缺乏导致的颅内出血。所有这些儿童均为纯母乳喂养。为了评估纯母乳喂养婴儿中维生素K依赖凝血因子的潜在缺乏情况，我们测定了204名健康婴儿在出生第5天和出生第5周时的凝血酶原凝血时间，并将结果与喂养方式相关联。在出生第5天，纯母乳喂养婴儿的凝血酶原凝血时间明显长于仅接受配方奶或同时接受配方奶和母乳的婴儿。因此，应重新研究纯母乳喂养新生儿的维生素K供应情况。然而，在出生第5周时，纯母乳喂养婴儿与纯配方奶喂养或混合喂养婴儿的凝血酶原凝血时间并无差异。
