Awujoola Adeola O, Torga Ana P, Valencia Jose E, Alemneh Hermella, Prince Olaseni P, Kant Sandipagu P
Department of Pediatric Cardiology, Duke University Hospital, Durham, NC 27710, USA.
Children's National Hospital, Washington, DC 20010, USA.
Children (Basel). 2024 Oct 23;11(11):1277. doi: 10.3390/children11111277.
: The evaluation of metabolic syndrome (MetS) is critical among children and adolescents as it can predict cardiovascular disease in adulthood. The TG/HDL-C ratio has the best predictive accuracy among the different lipid ratios. This study aims to evaluate the prevalence and factors associated with a high TG/HDL-C ratio and the predictive accuracy for pediatric MetS. : This is a cross-sectional study of adolescents aged 9-21 to determine the prevalence of and associations between an elevated TG/HDL-C ratio and MetS. A ROC curve analysis was performed to determine the predictive accuracy of TG/HDL-C with MetS. : Of the 604 subjects, 29.8% had elevated TG/HDL-C, MetS was identified in 28.2%, and 54.5% were obese. Among patients with MetS, those with obesity were more likely to have an elevated TG/HDL-C ratio compared to those with a normal BMI (64% vs. 14%, < 0.05). Gender, obesity, ethnicity, and METS are significantly associated with a high TG/HDL-C ratio. TG/HDL-C has a good discriminatory ability to distinguish patients with MetS from those without (AUC 0.65, < 0.05). : The TG/HDL-C ratio was able to distinguish between children and adolescents with MetS. Hence, the TG/HDL-C ratio may be used in the rapid risk assessment of pediatric MetS, especially in those with obesity.
对儿童和青少年进行代谢综合征（MetS）评估至关重要，因为它可以预测成年后的心血管疾病。在不同的血脂比值中，TG/HDL-C比值具有最佳的预测准确性。本研究旨在评估高TG/HDL-C比值的患病率、相关因素以及对儿童代谢综合征的预测准确性。
这是一项针对9至21岁青少年的横断面研究，以确定TG/HDL-C比值升高与代谢综合征之间的患病率及关联。进行ROC曲线分析以确定TG/HDL-C对代谢综合征的预测准确性。
在604名受试者中，29.8%的人TG/HDL-C升高，28.2%的人被诊断为代谢综合征，54.5%的人肥胖。在患有代谢综合征的患者中，肥胖患者比BMI正常的患者更有可能出现TG/HDL-C比值升高（64%对14%，<0.05）。性别、肥胖、种族和代谢综合征与高TG/HDL-C比值显著相关。TG/HDL-C具有良好的区分能力，可将患有代谢综合征的患者与未患代谢综合征的患者区分开来（AUC 0.65，<0.05）。
TG/HDL-C比值能够区分患有代谢综合征的儿童和青少年。因此，TG/HDL-C比值可用于儿童代谢综合征的快速风险评估，尤其是在肥胖儿童中。
