利用甘油三酯/高密度脂蛋白胆固醇比值和总胆固醇/高密度脂蛋白胆固醇比值评估青少年代谢综合征的风险

Risk assessment of metabolic syndrome in adolescents using the triglyceride/high-density lipoprotein cholesterol ratio and the total cholesterol/high-density lipoprotein cholesterol ratio.

作者信息

Chu Shou-Yu, Jung Ji-Hyun, Park Mi-Jung, Kim Shin-Hye

机构信息

Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.

出版信息

Ann Pediatr Endocrinol Metab. 2019 Mar;24(1):41-48. doi: 10.6065/apem.2019.24.1.41. Epub 2019 Mar 31.

DOI:10.6065/apem.2019.24.1.41

PMID:30943679

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449623/

Abstract

PURPOSE

This study was conducted to investigate the distributions of the triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C) ratio and total cholesterol (TC) to HDL-C ratio, and to explore their usefulness as markers of metabolic syndrome (MetS) in Korean adolescents.

METHODS

We obtained data for 2,721 adolescents (1,436 boys and 1,285 girls) aged 10-18 years who participated in the Korean National Health and Nutrition Examination Surveys from 2008 to 2010. International Diabetes Federation criteria were used to define MetS.

RESULTS

There were no significant gender-related differences in TG/HDL-C or TC/HDL-C ratios. These lipid ratios showed significant associations with homeostatic model assessment for insulin resistance (HOMA-IR) and waist circumference. Areas under the receiver operating characteristic curve to identify MetS were 0.947 for TG/HDL-C and 0.924 for TC/HDL-C, which were higher than that of HOMA-IR (0.822). Optimal cutoff values (sensitivity, specificity) of TG/HDL-C and TC/HDL-C ratios for MetS prediction were 3.3 (85.7%, 89.9%), and 3.8 (92.9%, 82.8%), respectively. Odds ratio (OR; 95% confidence intervals [CIs]) for MetS in adolescents with TC/HDL-C ratio above the cutoff value was 14.8 (2.8-77.4), while that for TG/HDL-C ratio about the cutoff value was 30.6 (6.0-157.6). In adolescents who had both lipid ratios above the cutoff values, the OR (95% CI) for MetS was 36.2 (7.2-186.2).

CONCLUSION

TG/HDL-C and TC/HDL-C ratios are useful markers of metabolic syndrome with high predictive value in Korean adolescents.

摘要

目的

本研究旨在调查甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）的比值以及总胆固醇（TC）与HDL-C的比值的分布情况，并探讨它们作为韩国青少年代谢综合征（MetS）标志物的实用性。

方法

我们获取了2008年至2010年参加韩国国民健康与营养检查调查的2721名10至18岁青少年（1436名男孩和1285名女孩）的数据。采用国际糖尿病联盟标准来定义MetS。

结果

TG/HDL-C或TC/HDL-C比值在性别上无显著差异。这些血脂比值与胰岛素抵抗的稳态模型评估（HOMA-IR）和腰围显著相关。用于识别MetS的受试者工作特征曲线下面积，TG/HDL-C为0.947，TC/HDL-C为0.924，高于HOMA-IR（0.822）。MetS预测中TG/HDL-C和TC/HDL-C比值的最佳截断值（敏感性、特异性）分别为3.3（85.7%，89.9%）和3.8（92.9%，82.8%）。TC/HDL-C比值高于截断值的青少年患MetS的比值比（OR；95%置信区间[CI]）为14.8（2.8 - 77.4），而TG/HDL-C比值高于截断值的为30.6（6.0 - 157.6）。在两个血脂比值均高于截断值的青少年中，患MetS的OR（95%CI）为36.2（7.2 - 186.2）。