Bellinato Francesco, Marocchi Maria, Pecoraro Luca, Zaffanello Marco, Del Giglio Micol, Girolomoni Giampiero, Piacentini Giorgio, Rigotti Erika
Department of Medicine, Section of Dermatology, University of Verona, 37126 Verona, Italy.
Pediatric Unit, Department of Surgical Sciences, Destiny, Gynecology and Pediatrics, University of Verona, 37126 Verona, Italy.
Children (Basel). 2024 Nov 18;11(11):1397. doi: 10.3390/children11111397.
Infantile haemangiomas (IHs) affect 3-10% of infants, 10% of whom need topical or systemic beta-blocker therapy. Propranolol is the first choice for IHs with a high risk of complications. Since more than half of IHs leave a permanent mark, to reduce outcomes, it is essential to start oral propranolol (2-3 mg/kg/day in 2 doses/day) within the 5th month of life (i.e., during the proliferative phase) and to complete the therapy cycle for at least 6 months. This review aims to summarise the epidemiology, clinical presentation, diagnosis, and treatment of IHs and to highlight the importance of proper referral to specialised hub centres. Patients with vascular anomalies, particularly those suspected of having IH, should be referred to a specialised centre for accurate diagnosis, management by a multidisciplinary team, and timely treatment. IHs may pose life-threatening, functional, and aesthetic risks or may ulcerate. Segmental infantile haemangioma of the face/neck and the lumbosacral regions can be associated with various malformations. To ensure timely specialist evaluation and treatment to reduce the potential risk of complications, it is essential to identify high-risk IHs rapidly. The Infantile Haemangioma Referral Score (IHReS) scale is an important tool to assist primary care paediatricians and general dermatologists.
婴儿血管瘤(IHs)影响3%-10%的婴儿,其中10%的婴儿需要局部或全身使用β受体阻滞剂治疗。普萘洛尔是有高并发症风险的婴儿血管瘤的首选治疗药物。由于超过半数的婴儿血管瘤会留下永久性痕迹,为降低不良后果,在婴儿出生后第5个月(即增殖期)开始口服普萘洛尔(2-3毫克/千克/天,分2次服用)并完成至少6个月的治疗周期至关重要。本综述旨在总结婴儿血管瘤的流行病学、临床表现、诊断和治疗,并强调转诊至专业中心的重要性。患有血管异常的患者,尤其是疑似患有婴儿血管瘤的患者,应转诊至专业中心进行准确诊断、由多学科团队进行管理并及时治疗。婴儿血管瘤可能会带来危及生命、影响功能和美观的风险,或可能发生溃疡。面部/颈部和腰骶部的节段性婴儿血管瘤可能与各种畸形有关。为确保及时进行专科评估和治疗以降低潜在并发症风险,快速识别高风险婴儿血管瘤至关重要。婴儿血管瘤转诊评分(IHReS)量表是协助初级保健儿科医生和普通皮肤科医生的重要工具。