Department of Oral and Maxillofacial Surgery, Qilu Hospital, and Institute of Stomatology, Shandong University, Jinan, 250012, China.
School of Stomatology, Shandong University, Jinan, 250012, China.
Sci Rep. 2017 Mar 23;7(1):342. doi: 10.1038/s41598-017-00495-z.
Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2.0 mg/kg/day. We evaluated the therapeutic responses 6 months after treatment and the end of treatment, which were categorized into four grades. The type and location of the lesions and the infant age at treatment initiation were analysed. The clinical response rate (III + IV) was 91.72% at 6 months after treatment and 97.63% at the end of treatment. The average treatment duration was 9.99 (2-24) months. The group aged 4-6 months exhibited a greater therapeutic response rate (98.48%). The treatment duration was shorter (9.52 months) for mixed-type IHs. Better therapeutic responses were observed for IHs located around the parotid, periorbital, cheek, and neck regions and for multiple IH lesions. Our study indicated that propranolol is effective for IHs affecting the head and neck. The age at treatment initiation and the location of the lesions had a significant effect on the therapeutic response, whereas the lesion type might affect the treatment duration.
婴儿血管瘤（IHs）是婴儿期最常见的先天性血管肿瘤。普萘洛尔已被证明对 IHs 有效；然而，影响其治疗效果的因素尚不清楚。我们招募了 169 名患有头颈部 IH 的婴儿，每天口服普萘洛尔 2.0mg/kg。我们在治疗后 6 个月和治疗结束时评估了治疗反应，并将其分为四个等级。分析了病变的类型和位置以及婴儿开始治疗时的年龄。治疗后 6 个月的临床反应率（III+IV）为 91.72%，治疗结束时为 97.63%。平均治疗时间为 9.99（2-24）个月。4-6 个月龄组的治疗反应率更高（98.48%）。混合型 IHs 的治疗时间较短（9.52 个月）。在腮腺、眶周、脸颊和颈部周围以及多发性 IH 病变中，观察到更好的治疗反应。我们的研究表明，普萘洛尔对影响头颈部的 IHs 有效。治疗开始时的年龄和病变部位对治疗反应有显著影响，而病变类型可能影响治疗持续时间。
