Ucci Argia, Giacchi Luca, Rucci Nadia
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Biomedicines. 2024 Oct 25;12(11):2451. doi: 10.3390/biomedicines12112451.
Bone is the preferential site of metastasis for the most common tumors, including breast cancer. On the other hand, osteosarcoma is the primary bone cancer that most commonly occurs and causes bone cancer-related deaths in children. Several treatment strategies have been developed so far, with little or no efficacy for patient survival and with the development of side effects. Therefore, there is an urgent need to develop more effective therapies for bone primary tumors and bone metastatic disease. This almost necessarily requires the use of in vivo animal models that better mimic human pathology and at the same time follow the ethical principles for the humane use of animal testing. In this review we aim to illustrate the main and more suitable in vivo strategies employed to model bone metastases and osteosarcoma. We will also take a look at the recent technologies implemented for a partial replacement of animal testing.
骨骼是包括乳腺癌在内的最常见肿瘤转移的优先部位。另一方面，骨肉瘤是儿童中最常发生且导致骨癌相关死亡的原发性骨癌。到目前为止，已经开发了几种治疗策略，但对患者生存几乎没有疗效，并且会产生副作用。因此，迫切需要开发更有效的骨原发性肿瘤和骨转移性疾病治疗方法。这几乎必然需要使用能更好模拟人类病理同时遵循动物实验人道使用伦理原则的体内动物模型。在本综述中，我们旨在阐述用于模拟骨转移和骨肉瘤的主要且更合适的体内策略。我们还将审视为部分替代动物实验而实施的最新技术。
