Calderone Andrea, Latella Desirée, Impellizzeri Federica, de Pasquale Paolo, Famà Fausto, Quartarone Angelo, Calabrò Rocco Salvatore
Department of Clinical and Experimental Medicine, University of Messina, Piazza Pugliatti, 98122 Messina, Italy.
IRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C.da Casazza, 98124 Messina, Italy.
Biomedicines. 2024 Nov 15;12(11):2613. doi: 10.3390/biomedicines12112613.
Meditation and mindfulness, rooted in ancient traditions, enhance mental well-being by cultivating awareness and emotional control. It has been shown to induce neuroplasticity, increase cortical thickness, reduce amygdala reactivity, and improve brain connectivity and neurotransmitter levels, leading to improved emotional regulation, cognitive function, and stress resilience. This systematic review will synthesize research on neurobiological changes associated with mindfulness and meditation practices. Studies were identified from an online search of PubMed, Web of Science, Cochrane Library, and Embase databases without any search time range. This review has been registered on Open OSF (n) GV2JY. Mindfulness-Based Stress Reduction (MBSR) enhances brain regions related to emotional processing and sensory perception, improves psychological outcomes like anxiety and depression, and exhibits unique mechanisms of pain reduction compared to placebo. This review highlights that mindfulness, particularly through MBSR, improves emotional regulation and brain structure, reduces anxiety, and enhances stress resilience. Future research should focus on diverse populations and naturalistic settings to better understand and optimize these benefits.
冥想和正念源于古老传统，通过培养意识和情绪控制来提升心理健康。研究表明，它能诱导神经可塑性，增加皮质厚度，降低杏仁核反应性，改善大脑连通性和神经递质水平，从而改善情绪调节、认知功能和压力恢复力。本系统综述将综合有关正念和冥想练习相关神经生物学变化的研究。通过对PubMed、科学网、Cochrane图书馆和Embase数据库进行在线搜索来确定研究，且无任何搜索时间范围限制。本综述已在Open OSF（n）GV2JY上注册。基于正念的减压疗法（MBSR）可增强与情绪处理和感官知觉相关的脑区，改善焦虑和抑郁等心理状况，并且与安慰剂相比，展现出独特的疼痛减轻机制。本综述强调，正念，尤其是通过MBSR，可改善情绪调节和大脑结构，减轻焦虑，并增强压力恢复力。未来的研究应关注不同人群和自然环境，以更好地理解和优化这些益处。
