Zhang Ruiting, Yang Jia, Wang Qingjie, Hu Dandan, Zhao Qiping, Zhu Shunhai, Qiao Yu, Zhao Fanghe, Wang Zhongchuang, Wang Jinwen, Yu Yu, Han Hongyu, Hao Lili, Dong Hui
Key Laboratory of Animal Parasitology of Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Minhang, Shanghai 200241, China.
College of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Animals (Basel). 2024 Nov 18;14(22):3312. doi: 10.3390/ani14223312.
Necrotic enteritis (NE), caused by , represents a major economic challenge to poultry production. This study evaluated the effects of four plant extracts-, pomegranate peel, , and -in combination with , as potential antibiotic alternatives for controlling NE. Using an experimentally induced NE model produced by coinfection with and , 288 chickens were divided into 12 groups to assess growth performance, intestinal lesions, and inflammatory markers. Compared with the enramycin group, the pomegranate peel extract group had a 9.9% increase in body weight gain (BWG), significant enhancement in expression, and reduced production of inflammatory factors. Compared with the infected control group, the combination of extract and resulted in the lowest intestinal lesion scores. The , , and zonula occludens-1 expression levels in the group treated with extract combined with increased to the highest levels compared to those in the healthy control group. These findings emphasize the potential of plant extracts, particularly pomegranate peel and with , as natural alternatives for NE management in poultry, providing a promising approach to reducing reliance on antibiotics.
坏死性肠炎（NE）由[未提及病因]引起，是家禽生产面临的一项重大经济挑战。本研究评估了四种植物提取物——石榴皮、[未提及提取物名称]、[未提及提取物名称]以及与[未提及物质]联合使用，作为控制坏死性肠炎的潜在抗生素替代品的效果。利用由[未提及两种病原体名称]共同感染产生的实验性坏死性肠炎模型，将288只鸡分为12组，以评估生长性能、肠道病变和炎症标志物。与恩拉霉素组相比，石榴皮提取物组体重增加（BWG）提高了9.9%，[未提及基因名称]表达显著增强，炎症因子产生减少。与感染对照组相比，[未提及提取物名称]提取物与[未提及物质]的组合导致肠道病变评分最低。与健康对照组相比，用[未提及提取物名称]提取物与[未提及物质]联合处理的组中，[未提及基因名称]、[未提及基因名称]和紧密连接蛋白-1的表达水平升至最高。这些发现强调了植物提取物，特别是石榴皮和[未提及提取物名称]与[未提及物质]联合使用，作为家禽坏死性肠炎管理天然替代品的潜力，为减少对抗生素的依赖提供了一种有前景的方法。
