Department of Medicine, University of California, San Francisco, CA 94158, USA.
Quantitative Biosciences Institute, Department of Medicine, University of California, San Francisco, CA 94158, USA.
Biomolecules. 2024 Oct 31;14(11):1387. doi: 10.3390/biom14111387.
One-carbon (1C) metabolism is a complex network of metabolic reactions closely related to producing 1C units (as methyl groups) and utilizing them for different anabolic processes, including nucleotide synthesis, methylation, protein synthesis, and reductive metabolism. These pathways support the high proliferative rate of cancer cells. While drugs that target 1C metabolism (like methotrexate) have been used for cancer treatment, they often have significant side effects. Therefore, developing new drugs with minimal side effects is necessary for effective cancer treatment. Methionine, glycine, and serine are the main three precursors of 1C metabolism. One-carbon metabolism is vital not only for proliferative cells but also for non-proliferative cells in regulating energy homeostasis and the aging process. Understanding the potential role of 1C metabolism in aging is crucial for advancing our knowledge of neoplastic progression. This review provides a comprehensive understanding of the molecular complexities of 1C metabolism in the context of cancer and aging, paving the way for researchers to explore new avenues for developing advanced therapeutic interventions for cancer.
一碳（1C）代谢是一个复杂的代谢反应网络，与产生 1C 单位（如甲基）以及将其用于不同的合成代谢过程密切相关，包括核苷酸合成、甲基化、蛋白质合成和还原代谢。这些途径支持癌细胞的高增殖率。虽然靶向 1C 代谢的药物（如甲氨蝶呤）已被用于癌症治疗，但它们通常有显著的副作用。因此，开发副作用最小的新药对于有效的癌症治疗是必要的。蛋氨酸、甘氨酸和丝氨酸是 1C 代谢的主要三种前体。一碳代谢不仅对增殖细胞，而且对非增殖细胞在调节能量平衡和衰老过程中都至关重要。了解 1C 代谢在衰老中的潜在作用对于推进我们对肿瘤进展的认识至关重要。本综述提供了对癌症和衰老背景下 1C 代谢分子复杂性的全面理解，为研究人员探索开发用于癌症的先进治疗干预措施的新途径铺平了道路。
Zotero 插件
