Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Biomolecules. 2024 Nov 5;14(11):1408. doi: 10.3390/biom14111408.
Cerebrovascular diseases (CVDs), comprising predominantly ischemic stroke and chronic cerebral hypoperfusion (CCH), are a significant threat to global health, often leading to disability and mortality. Remote ischemic conditioning (RIC) has emerged as a promising, non-pharmacological strategy to combat CVDs by leveraging the body's innate defense mechanisms. This review delves into the neuroprotective mechanisms of RIC, categorizing its effects during the acute and chronic phases of stroke recovery. It also explores the synergistic potential of RIC when combined with other therapeutic strategies, such as pharmacological treatments and physical exercise. Additionally, this review discusses the pathways through which peripheral transmission can confer central neuroprotection. This review concludes by addressing the challenges regarding and future directions for RIC, emphasizing the need for standardized protocols, biomarker identification, and expanded clinical trials to fully realize its therapeutic potential.
脑血管疾病（CVDs）主要包括缺血性中风和慢性脑灌注不足（CCH），严重威胁着全球健康，常导致残疾和死亡。远程缺血预处理（RIC）作为一种有前途的非药物治疗策略，通过利用身体的天然防御机制来对抗 CVDs。本综述深入探讨了 RIC 的神经保护机制，将其在中风恢复的急性期和慢性期的作用进行分类。还探讨了 RIC 与其他治疗策略（如药物治疗和体育锻炼）联合应用的协同潜力。此外，本综述还讨论了外周传递途径如何发挥中枢神经保护作用。最后，本综述讨论了 RIC 面临的挑战和未来方向，强调需要制定标准化方案、确定生物标志物以及扩大临床试验，以充分发挥其治疗潜力。
