School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.
Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda 151401, India.
Int J Environ Res Public Health. 2024 Oct 29;21(11):1439. doi: 10.3390/ijerph21111439.
The I/D polymorphism has been suggested to be associated with multiple chronic diseases and sports modalities, which has public health implications for global populations and sport performance. This updated review aims to strengthen the association and identify sporting disciplines that are most influenced by the gene polymorphism using a meta-analysis approach.
Published studies on the association between the I/D polymorphism and elite endurance and power were collected until 15 June 2024. The studies on public health-associated sports like running, swimming, and cycling were systematically reviewed following pre-agreed criteria, and a meta-analysis was carried out using different genetic models.
A total of 137 studies were identified in the literature search and screened. There was a significant association between elite endurance and the II genotype compared with healthy inactive controls (OR, 1.54; 95%CI, 1.24-1.91) and elite power athletes (OR = 1.56; 95%CI = 1.07-2.28). Specifically, runners and triathletes were associated with the II genotype compared with controls (OR = 1.76; 95%CI = 1.26-2.47; -value = 0.001 and OR = 2.69; 95%CI = 1.15-6.32, -value = 0.023, respectively). Additionally, endurance swimmers were associated with the II genotype compared with short-distance, power swimmers (OR = 2.27; 95%CI = 1.49-3.45; -value < 0.001).
The meta-analysis results confirm and strengthen the association between elite endurance and the I/D polymorphism in different sporting modalities, which may have implications for public health and sports participation.
I/D 多态性与多种慢性疾病和运动方式有关，这对全球人口的公共健康和运动表现都有影响。本综述旨在通过荟萃分析方法加强关联，并确定受基因多态性影响最大的运动项目。
收集截至 2024 年 6 月 15 日关于 I/D 多态性与精英耐力和力量关系的已发表研究。按照预先商定的标准对与跑步、游泳和自行车等与公共健康相关的运动的研究进行系统综述，并使用不同的遗传模型进行荟萃分析。
在文献检索中总共确定了 137 项研究，并进行了筛选。与健康不活跃的对照组相比，精英耐力与 II 基因型之间存在显著关联（OR，1.54；95%CI，1.24-1.91）和精英力量运动员（OR=1.56；95%CI=1.07-2.28）。具体而言，与对照组相比，跑步者和三项全能运动员与 II 基因型相关（OR=1.76；95%CI=1.26-2.47；P 值=0.001 和 OR=2.69；95%CI=1.15-6.32，P 值=0.023）。此外，与短距离、力量游泳运动员相比，耐力游泳运动员与 II 基因型相关（OR=2.27；95%CI=1.49-3.45；P 值<0.001）。
荟萃分析结果证实并加强了不同运动项目中精英耐力与 I/D 多态性的关联，这可能对公共健康和运动参与具有重要意义。
