磷酸肌醇对冠状动脉循环不足患者的治疗。双盲临床试验。
Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double-blind clinical trial.
作者信息
Barlattani M, Guglielmi G, Mammarella A
出版信息
Arzneimittelforschung. 1979;29(9a):1483-5.
PMID:395958
Abstract
N-Methyl-N-(beta-hydroxyethyl) guanidine O-phosphate (creatinol O-phosphate, COP) was checked on patients suffering from inadequate coronary circulation (12 patients had a recent myocardial infarction and 13 were suffering from angina pectoris) versus a reference substance (solvent of COP) in a double blind study. COP improved rhythm disturbances, chest pains and symptoms of contractility failure to a statistically significant degree.
摘要
在一项双盲研究中，对冠状动脉循环不足的患者（12例近期发生心肌梗死，13例患有心绞痛）使用N-甲基-N-（β-羟乙基）胍磷酸酯（肌醇磷酸酯，COP），并与参考物质（COP的溶剂）进行对照。COP在改善心律失常、胸痛和收缩力衰竭症状方面具有统计学意义。
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