Eisinger J, Dagorn J
Magnesium. 1986;5(1):27-32.
Administration of vitamin B6 at doses of 1 and 1.5 g/day, for 2-7 weeks, showed that only the high doses increased erythrocyte magnesium. Similarly, magnesium balance studies in subjects receiving 500, 1,000 and 1,500 mg/day of vitamin B6 for 8 days showed that doses of 1 g or less had no effect upon the intestinal absorption of magnesium. In view of the existence of reversible neurological complications in subjects taking 2 g of pyridoxine per day, the use of very high doses of vitamin B6 must be considered as inadvisable, even if effective. A study of the long-term effects, and upon leukocyte magnesium, of doses of 1 g or less would be desirable.
每天服用1克和1.5克剂量的维生素B6，持续2至7周，结果显示只有高剂量能增加红细胞镁含量。同样，对每天服用500毫克、1000毫克和1500毫克维生素B6，持续8天的受试者进行的镁平衡研究表明，1克或更低剂量对镁的肠道吸收没有影响。鉴于每天服用2克吡哆醇的受试者存在可逆性神经并发症，即使高剂量维生素B6有效，也必须认为使用非常高剂量是不可取的。对1克或更低剂量的长期影响以及对白细胞镁含量的影响进行研究是很有必要的。
