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回归时间、细胞、系统与衰老:四、关于冈珀茨生存动力学的进一步思考——新生儿期

A return to time, cells, systems, and aging: IV. Further thoughts on Gompertzian survival dynamics--the neonatal years.

作者信息

Witten M

出版信息

Mech Ageing Dev. 1986 Jan;33(2):177-90. doi: 10.1016/0047-6374(86)90026-6.

Abstract

In this paper, I attempt to address the problem of how to model the survival curve in the early lifespan years; the neonatal years. I present a general model for a two group population in which the first group represents early stage failure and the second group represents the classical Gompertzian failure. After calculating the instantaneous failure rate for this population, I compare it to the single group Gompertzian with log-linear instantaneous failure rate. The theoretical results are then compared to the known biological data. It is demonstrated that this new model embeds, within itself, a variety of the known biological survival dynamics.

摘要

在本文中,我试图解决如何对生命早期阶段(即新生儿期)的生存曲线进行建模的问题。我提出了一个针对两组人群的通用模型,其中第一组代表早期失效,第二组代表经典的冈珀茨失效。在计算出该人群的瞬时失效率后,我将其与具有对数线性瞬时失效率的单组冈珀茨模型进行比较。然后将理论结果与已知的生物学数据进行比较。结果表明,这个新模型本身包含了各种已知的生物生存动态。

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