Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Research Center of the Basic Discipline of Cell Biology, Hebei Collaboration Innovation Center for Cell Signaling and Environmental Adaptation, Hebei Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang 050024, China.
Int J Mol Sci. 2024 Nov 13;25(22):12187. doi: 10.3390/ijms252212187.
As sessile organisms, the plant immune system plays a vital role in protecting plants from the widespread pathogens in the environment. The (Arabidopsis) receptor-like cytoplasmic kinase BOTRYTIS-INDUCED KINASE1 (BIK1) acts as a central regulator during plant immunity. As such, not only the BIK1 protein accumulation but also the attenuation is tightly regulated to ensure effective immune responses. Recent studies have highlighted the critical roles of ubiquitination in maintaining BIK1 homeostasis. Here, we review the latest advances in the ubiquitination of BIK1 in plant immunity, which is mediated by ubiquitin ligases PUB25/26, RHA3A/B, RGLG1/2, and PUB4. Additionally, we summarize and discuss the sites and types of BIK1 ubiquitination. Collectively, these analyses not only illustrate that the differential modifications on BIK1 by multiple ubiquitin ligases hold a crucial position in plant immunity but also provide a good example for future studies on ubiquitin-mediated modifications in plants.
作为固着生物，植物免疫系统在保护植物免受环境中广泛存在的病原体侵害方面发挥着至关重要的作用。（拟南芥）受体样细胞质激酶 BO 菌素诱导激酶 1（BIK1）在植物免疫中充当中央调节剂。因此，不仅 BIK1 蛋白的积累，而且衰减都受到严格调控，以确保有效的免疫反应。最近的研究强调了泛素化在维持 BIK1 体内平衡中的关键作用。在这里，我们回顾了泛素化在植物免疫中的最新进展，该过程由泛素连接酶 PUB25/26、RHA3A/B、RGLG1/2 和 PUB4 介导。此外，我们总结并讨论了 BIK1 泛素化的位点和类型。总的来说，这些分析不仅说明了多个泛素连接酶对 BIK1 的不同修饰在植物免疫中具有重要地位，而且为植物中泛素介导的修饰的未来研究提供了一个很好的范例。
