Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke 329-0498, Japan.
School of Medicine, Faculty of Medicine, Gunma University, Maebashi 371-8511, Japan.
Int J Mol Sci. 2024 Nov 19;25(22):12420. doi: 10.3390/ijms252212420.
Emerging evidence has indicated a possible link between attenuation of contractility in aortic smooth muscle cells and pathogenesis of aortic dissection, as revealed through comprehensive, multi-omic analyses of familial thoracic aortic aneurysm and dissection models. While L-type voltage-gated calcium channels have been extensively investigated for their roles in smooth muscle contraction, more recent investigations have suggested that downregulation of T-type voltage-gated calcium channels, rather than their L-type counterparts, may be more closely associated with impaired contractility observed in vascular smooth muscle cells. This review provides a detailed examination of T-type voltage-gated calcium channels, highlighting their structure, electrophysiology, biophysics, expression patterns, functional roles, and potential mechanisms through which their downregulation may contribute to reduced contractile function. Furthermore, the application of multi-omic approaches in investigating calcium channels is discussed.
新兴证据表明，主动脉平滑肌细胞收缩功能减弱与主动脉夹层的发病机制之间可能存在关联，这是通过对家族性胸主动脉瘤和夹层模型进行全面的多组学分析得出的。尽管 L 型电压门控钙通道在平滑肌收缩中的作用已被广泛研究，但最近的研究表明，下调 T 型电压门控钙通道，而不是 L 型钙通道，可能与血管平滑肌细胞中观察到的收缩功能障碍更为密切相关。本综述详细探讨了 T 型电压门控钙通道，强调了其结构、电生理学、生物物理学、表达模式、功能作用以及其下调可能导致收缩功能降低的潜在机制。此外，还讨论了多组学方法在钙通道研究中的应用。
