Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.
Lucio Lascaray Research Center, 01006 Vitoria-Gasteiz, Spain.
Int J Mol Sci. 2024 Nov 19;25(22):12434. doi: 10.3390/ijms252212434.
Metabolic syndrome refers to the simultaneous occurrence of several disorders that have been associated with other co-morbidities, such as a pro-inflammatory state and non-alcoholic fatty liver disease. Nowadays, it is a growing public health problem that contributes to the development of non-communicable diseases, such as type 2 diabetes, cardiovascular disease, and cognitive deficits among others. Its incidence has been related to modifiable lifestyle factors, mainly dietary patterns and physical activity. In addition, numerous studies have observed the potential beneficial effects of polyphenols in the prevention and treatment of metabolic syndrome components in both animals and humans. In this line, the aim of this review is to present the scientific evidence available about the beneficial effects of the phenolic compound xanthohumol in the prevention and/or treatment of obesity, dyslipidemia, insulin resistance, and fatty liver, which are important components of metabolic syndrome. All the potential beneficial effects described in this manuscript have been observed in vitro and in animal models, there are no published clinical trials in this context yet.
代谢综合征是指几种疾病同时发生，这些疾病与其他合并症有关，如炎症状态和非酒精性脂肪肝。如今，它是一个日益严重的公共卫生问题，导致了非传染性疾病的发展，如 2 型糖尿病、心血管疾病和认知缺陷等。其发病率与可改变的生活方式因素有关，主要是饮食模式和身体活动。此外，许多研究观察到多酚在预防和治疗动物和人类代谢综合征成分方面的潜在有益作用。在这方面，本综述的目的是介绍关于酚类化合物黄腐酚在预防和/或治疗肥胖、血脂异常、胰岛素抵抗和脂肪肝方面的有益作用的现有科学证据，这些都是代谢综合征的重要组成部分。本手稿中描述的所有潜在有益作用都已在体外和动物模型中观察到，但目前尚未在这方面发表临床试验。
