Cervantes-Salazar Jorge L, Pérez-Hernández Nonanzit, Calderón-Colmenero Juan, Rodríguez-Pérez José Manuel, González-Pacheco María G, Villamil-Castañeda Clara, Rosas-Tlaque Angel A, Ortega-Zhindón Diego B
Department of Pediatric Cardiac Surgery and Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Biology (Basel). 2024 Nov 7;13(11):911. doi: 10.3390/biology13110911.
Congenital heart diseases (CHDs) are a group of complex diseases characterized by structural and functional malformations during development in the human heart; they represent an important problem for public health worldwide. Within these malformations, septal defects such as ventricular (VSD) and atrial septal defects (ASD) are the most common forms of CHDs. Studies have reported that CHDs are the result of genetic and environmental factors. Here, we review and summarize the role of genetics involved in cardiogenesis and congenital cardiac septal defects. Moreover, treatment regarding these congenital cardiac septal defects is also addressed.
先天性心脏病（CHDs）是一组复杂的疾病，其特征是人类心脏在发育过程中出现结构和功能畸形；它们是全球公共卫生的一个重要问题。在这些畸形中，室间隔缺损（VSD）和房间隔缺损（ASD）等间隔缺损是先天性心脏病最常见的形式。研究报告称，先天性心脏病是遗传和环境因素共同作用的结果。在此，我们回顾并总结了遗传学在心脏发生和先天性心脏间隔缺损中所起的作用。此外，还讨论了针对这些先天性心脏间隔缺损的治疗方法。
