Bańkosz Magdalena
Cracow University of Technology, CUT Doctoral School, Faculty of Materials Engineering and Physics, Department of Material Engineering, 31-864 Cracow, Poland.
Materials (Basel). 2024 Nov 12;17(22):5502. doi: 10.3390/ma17225502.
This study focuses on the selection and evaluation of a kinetic model for the release of vitamin C from different delivery systems, including microcapsules, hydrogels, and a hybrid system combining both. The microcapsules were synthesized from a 2% sodium alginate solution and with vitamin C incorporated in selected formulations. Hydrogels were obtained through photopolymerization using poly(ethylene glycol) diacrylate and polyvinyl alcohol, with and without the addition of vitamin C. The hybrid system incorporated the vitamin C-containing microcapsules within the hydrogel matrix. Physicochemical properties, such as density, porosity, and water vapor transmission rate (WVTR), were evaluated. Kinetic studies of vitamin C release were conducted under dynamic and static conditions, and the experimental data were fitted to six different kinetic models: zero-order, first-order, second-order, Higuchi, Korsmeyer-Peppas, and Hixson-Crowell. The Higuchi and Korsmeyer-Peppas models provided the best fit for most systems, indicating that the release is predominantly controlled by diffusion and, in dynamic conditions, swelling of the matrix. The hybrid system, while exhibiting slower release than the microcapsules and hydrogel alone, demonstrated more controlled and sustained release, which is advantageous for applications requiring prolonged action.
本研究聚焦于从不同递送系统（包括微胶囊、水凝胶以及二者结合的混合系统）中释放维生素C的动力学模型的选择与评估。微胶囊由2%的海藻酸钠溶液合成，在选定配方中加入了维生素C。水凝胶通过使用聚乙二醇二丙烯酸酯和聚乙烯醇进行光聚合制备，添加或不添加维生素C。混合系统是将含维生素C的微胶囊纳入水凝胶基质中。对密度、孔隙率和水蒸气透过率（WVTR）等物理化学性质进行了评估。在动态和静态条件下进行了维生素C释放的动力学研究，并将实验数据拟合到六种不同的动力学模型：零级、一级、二级、Higuchi、Korsmeyer-Peppas和Hixson-Crowell。Higuchi和Korsmeyer-Peppas模型对大多数系统拟合最佳，表明释放主要受扩散控制，在动态条件下还受基质溶胀控制。混合系统虽然比单独的微胶囊和水凝胶释放速度慢，但显示出更可控和持续的释放，这对于需要长效作用的应用是有利的。
