新西兰黑鼠中，地西泮敏感性的年龄依赖性增强加速。

Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice.

作者信息

Forster M J, Retz K C, Popper M D, Lal H

出版信息

Life Sci. 1986 Apr 14;38(15):1433-9. doi: 10.1016/0024-3205(86)90477-7.

Abstract

Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.

摘要

比较了不同年龄组的C57BL/6小鼠和自身免疫性新西兰黑（NZB）小鼠，观察地西泮诱导的共济失调和巴比妥类药物诱导的翻正反射消失情况。在1至3月龄之间，两个品系的小鼠在由地西泮诱导的共济失调方面，都表现出类似的与年龄相关的半数有效剂量（ED50）下降。然而，在3至12月龄之间，NZB小鼠的ED50下降明显更大。相比之下，两个品系的小鼠在己巴比妥或巴比妥诱导的翻正反射消失持续时间方面，与年龄相关的增加情况相似。结果表明，NZB小鼠对苯二氮䓬类药物的敏感性呈现相对加速的与年龄相关的增加，但对巴比妥类药物则不然。