Maris Mihaela, Martu Maria-Alexandra, Maris Marius, Martu Cristian, Anton Diana Maria, Pacurar Mariana, Earar Kamel
Faculty of Dental Medicine, University of Medicine and Pharmacy "Dunărea de Jos", 800201 Galati, Romania.
Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
J Clin Med. 2024 Nov 8;13(22):6724. doi: 10.3390/jcm13226724.
The purpose of this study was to assess the microbial composition and density of subgingival plaque samples for periodontal pathogens while correlating the values with glycemic control levels via glycated hemoglobin (HbA1c), a type of hemoglobin that has chemically linked glucose, in type I diabetes individuals who will undergo complex oral rehabilitation through orthodontic treatment and implant surgery. A cohort of 42 adults with type I diabetes were included in this study. The subjects sustained a comprehensive periodontal clinical examination as well as microbiological assessments of their subgingival plaque samples through quantitative real-time PCR. The samples were collected from the two deepest pockets of each subject. The highest number of periodontopathogenic bacteria was observed in the pockets of 5-7 mm. showed the highest prevalence (20.48%), with decreasing numbers as follows: (13.31%), (11.26%), (7%), and (4.9%). and were significantly more commonly observed in individuals with elevated HbA1c serum levels. No correlation was observed between , , presence, and the HbA1c value. Periodontopathogenic agents' presence in subgingival biofilm samples varied in accordance with the pocket probing depth and metabolic control of the diabetic individuals. In our study, the appearance of these periodontopathogenic agents was linked to lowered metabolic control in patients with type I diabetes mellitus.
本研究的目的是评估接受正畸治疗和种植手术以进行复杂口腔修复的I型糖尿病患者龈下菌斑样本中牙周病原体的微生物组成和密度，并通过糖化血红蛋白（HbA1c，一种与葡萄糖化学结合的血红蛋白）将这些值与血糖控制水平相关联。本研究纳入了42名成年I型糖尿病患者。受试者接受了全面的牙周临床检查，并通过定量实时PCR对其龈下菌斑样本进行了微生物学评估。样本从每个受试者的两个最深牙周袋中采集。在5-7毫米的牙周袋中观察到的牙周病原菌数量最多，显示出最高的患病率（20.48%），随后数量递减如下：（13.31%）、（11.26%）、（7%）和（4.9%）。在HbA1c血清水平升高的个体中，和的观察频率明显更高。未观察到、、的存在与HbA1c值之间存在相关性。龈下生物膜样本中牙周病原体的存在情况因糖尿病个体的牙周袋探诊深度和代谢控制情况而异。在我们的研究中，这些牙周病原体的出现与I型糖尿病患者代谢控制降低有关。
