Botezatu Ionut Catalin, Salceanu Mihaela, Botez Ana Emanuela, Dimitriu Cristina Daniela, Ciurcanu Oana Elena, Topoliceanu Claudiu, Cotrutz Elena-Carmen, Martu Maria-Alexandra
Department of Cell and Molecular Biology, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania.
Department of Odontology-Periodontology and Fixed Restorations, Faculty of Dental Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Dent J (Basel). 2025 Aug 18;13(8):373. doi: 10.3390/dj13080373.
The goal of this research was to determine the prevalence and distribution of the oro-maxillofacial pathologies in patients with diabetes mellitus and to determine the correlation between diabetes mellitus and oro-maxillofacial disorders. : The retrospective study group consisted of 6868 patients (mean age 49.84 ± 22.79 years) admitted in Oral and Maxillofacial Surgery Department between 2018 and 2024. Qualitative data were analyzed by Chi-square (χ) test. Odds Ratio (OR) and Relative Risk (RR) were measured for each oro-maxillofacial pathology. Quantitative data were analyzed by Student's T-test. : Among patients with diabetes mellitus (DM), the estimated risk of malignant tumors was 5.29 times higher (RR = 5.29; = 0.001) compared to the non-DM group, with 15.0% of diabetic patients affected, versus 1.4% in the non-diabetic group. The probability of periodontal disease in diabetic patients was 4.66 times higher (RR = 4.66; = 0.001), affecting 5.5% of the DM group, compared to only 0.6% in the non-DM group. Diabetic patients had a likelihood 3.53 times higher (RR = 3.53; = 0.001) of developing apical periodontitis, with 5.3% of the DM group affected, in contrast to 1.0% of the non-DM group. The presence of root remnants was 1.43 times more likely (RR = 1.43; = 0.001) in diabetic patients, with 9.0% of the DM group affected, compared to 6.1% in the non-DM group. : The strong correlation between diabetes and oral pathologies, particularly malignancies and periodontal disease, underscores the need for early screening, preventive care, and targeted management strategies for diabetic patients.
本研究的目的是确定糖尿病患者口腔颌面部病变的患病率和分布情况，并确定糖尿病与口腔颌面部疾病之间的相关性。回顾性研究组由2018年至2024年期间在口腔颌面外科住院的6868名患者组成（平均年龄49.84±22.79岁）。定性数据采用卡方（χ）检验进行分析。对每种口腔颌面部病变测量比值比（OR）和相对风险（RR）。定量数据采用学生t检验进行分析。在糖尿病（DM）患者中，恶性肿瘤的估计风险比非DM组高5.29倍（RR = 5.29；P = 0.001），15.0%的糖尿病患者受影响，而非糖尿病组为1.4%。糖尿病患者患牙周病的概率高4.66倍（RR = 4.66；P = 0.001），DM组中有5.5%受影响，而非DM组仅为0.6%。糖尿病患者发生根尖周炎的可能性高3.53倍（RR = 3.53；P = 0.001），DM组中有5.3%受影响，相比之下非DM组为1.0%。糖尿病患者出现牙根残留的可能性高1.43倍（RR = 1.43；P = 0.001），DM组中有9.0%受影响，而非DM组为6.1%。糖尿病与口腔病变，尤其是恶性肿瘤和牙周病之间的强相关性，突出了对糖尿病患者进行早期筛查、预防保健和针对性管理策略的必要性。
