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基于放射性白内障发生频率的剂量-效应关系

[Dose-effect relationship based on frequency of occurrence of radiation cataracts].

作者信息

Gerasimov V I, Ermolaeva-Makovskaia A P, Ramzaev P V

出版信息

Med Radiol (Mosk). 1986 Apr;31(4):52-5.

PMID:3959814
Abstract

The paper is concerned with the results of experiments on random bred mice concerning dose-effect relationship estimated by radiation cataract developing 1 year after x-ray irradiation at doses of 0.05, 0.5, 4, 7 and 10 Gy. It was shown that the effect of ionizing radiation on the lens registered by its opacity, could be threshold-free and described with the equation of the straight line. The authors found it appropriate to introduce a concept of a permissible risk dose causing a certain degree of cataract. In their opinion, the existing maximum tolerance radiation dose based on the absence of cataract at doses less than 7.5 Gy, should be lowered not less than by one order.

摘要

该论文关注的是对随机繁殖小鼠进行的实验结果,这些实验涉及通过在0.05、0.5、4、7和10 Gy剂量的X射线照射后1年发生的放射性白内障来估计剂量效应关系。结果表明,通过晶状体混浊所记录的电离辐射对晶状体的影响可能无阈值,并且可用直线方程来描述。作者发现引入一个导致一定程度白内障的可允许风险剂量的概念是合适的。他们认为,基于在小于7.5 Gy剂量下无白内障情况的现有最大耐受辐射剂量,应至少降低一个数量级。

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