Betancourt-Ángeles Mario, López-Callejas Régulo, Berrones-Stringel Guillermo, Jaramillo-Martínez César, Navarro-Luna Bryan, Rodríguez-Méndez Benjamín Gonzalo, Mercado-Cabrera Antonio, Valencia-Alvarado Raúl
Medical Center ISSEMyM Toluca, Av. Baja Velocidad 284 km. 57.5, San Jerónimo Chicahualco, Metepec 52170, Mexico.
Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac 52750, Mexico.
Life (Basel). 2024 Nov 8;14(11):1450. doi: 10.3390/life14111450.
Anastomotic leaks remain a significant challenge in intestinal surgery, often leading to severe complications. This study investigated a novel approach to enhance anastomotic healing and reduce the risk of leaks by combining traditional suturing and stapling techniques with non-thermal atmospheric pressure plasma (NTAPP) application. NTAPP, a cold atmospheric plasma generated through the ionization of ambient air, has been shown to possess antimicrobial, hemostatic, and wound-healing properties. NTAPP promotes sterilization, coagulation, and tissue regeneration by generating reactive oxygen and nitrogen species, potentially strengthening anastomotic union. This pilot study evaluated the efficacy of NTAPP in three patients undergoing intestinal anastomosis. Following the standard surgical procedure, NTAPP was applied directly to the anastomotic site. Postoperative outcomes were monitored for six months, including anastomotic leaks and healing rates. Preliminary results demonstrated promising outcomes. All three patients exhibited successful sealing of the anastomosis, with no evidence of leakage during the follow-up period, providing reassurance and confidence in the potential of sutures, staples, and NTAPP. These findings suggest that NTAPP can significantly improve the safety and efficacy of intestinal surgeries by reducing the incidence of anastomotic leaks. While further research with a larger sample is necessary to confirm these initial findings, the results of this study provide a strong foundation for exploring the potential of NTAPP as a valuable adjunct to conventional surgical techniques for preventing anastomotic leaks. This innovative approach could reduce postoperative complications, improve patient outcomes, and enhance the overall quality of care in intestinal surgery.
吻合口漏仍然是肠道手术中的一个重大挑战，常常导致严重并发症。本研究探讨了一种新方法，即通过将传统缝合和吻合器技术与非热大气压力等离子体（NTAPP）应用相结合，来促进吻合口愈合并降低漏出风险。NTAPP是通过对环境空气进行电离产生的冷大气等离子体，已被证明具有抗菌、止血和伤口愈合特性。NTAPP通过产生活性氧和氮物种促进杀菌、凝血和组织再生，有可能加强吻合口愈合。这项前瞻性研究评估了NTAPP在3例接受肠道吻合术患者中的疗效。按照标准手术程序，将NTAPP直接应用于吻合口部位。对术后结果进行了6个月的监测，包括吻合口漏和愈合率。初步结果显示出有前景的结果。所有3例患者的吻合口均成功封闭，随访期间无漏出迹象，这为缝合、吻合器和NTAPP的潜力提供了信心。这些发现表明，NTAPP可通过降低吻合口漏的发生率显著提高肠道手术的安全性和疗效。虽然需要更大样本的进一步研究来证实这些初步发现，但本研究结果为探索NTAPP作为预防吻合口漏的传统手术技术的有价值辅助手段的潜力提供了坚实基础。这种创新方法可减少术后并发症，改善患者预后，并提高肠道手术的整体护理质量。
