Han Bing, Chen Zhuying, Ruan Bing, Chen Yongjie, Lv Yuanyuan, Li Cui, Yu Laikang
Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China.
Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University, Beijing 100084, China.
Life (Basel). 2024 Nov 12;14(11):1470. doi: 10.3390/life14111470.
This study aimed to investigate the effects of inspiratory muscle training (IMT) on inspiratory muscle strength, dyspnea, and quality of life (QOL) in COPD patients. A comprehensive search was undertaken on the Web of Science, Scopus, Embase, Cochrane, and PubMed databases, encompassing data published up to 31 March 2024. A meta-analysis was subsequently conducted to quantify the standardized mean difference (SMD) and 95% confidence interval (CI) for the effects of IMT in COPD patients. Sixteen studies met the inclusion criteria. IMT significantly improved inspiratory muscle strength (SMD, 0.86, < 0.00001), dyspnea (SMD = -0.50, < 0.00001), and QOL (SMD = 0.48, = 0.0006). Subgroup analysis showed that <60% maximal inspiratory muscle pressure (PImax) IMT (inspiratory muscle strength, SMD = 1.22, = 0.005; dyspnea, SMD = -0.92, < 0.0001), IMT conducted for ≤20 min (inspiratory muscle strength, SMD = 0.97, = 0.008; dyspnea, SMD = -0.63, = 0.007; QOL, SMD = 1.66, = 0.007), and IMT conducted >3 times per week (inspiratory muscle strength, SMD = 1.06, < 0.00001; dyspnea, SMD = -0.54, < 0.00001; QOL, SMD = 0.48, = 0.0009) had greater effects. This meta-analysis provides clinicians with evidence supporting the recommendation that COPD patients engage in IMT at <60% PImax for more than 3 times per week, with each session lasting no more than 20 min, to improve inspiratory muscle strength, dyspnea, and QOL.
本研究旨在探讨吸气肌训练（IMT）对慢性阻塞性肺疾病（COPD）患者吸气肌力量、呼吸困难及生活质量（QOL）的影响。我们在科学网、Scopus、Embase、Cochrane和PubMed数据库进行了全面检索，纳入截至2024年3月31日发表的数据。随后进行荟萃分析，以量化IMT对COPD患者影响的标准化均值差（SMD）和95%置信区间（CI）。16项研究符合纳入标准。IMT显著改善了吸气肌力量（SMD，0.86，<0.00001）、呼吸困难（SMD = -0.50，<0.00001）和生活质量（SMD = 0.48，= 0.0006）。亚组分析表明，最大吸气肌压力（PImax）<60%的IMT（吸气肌力量，SMD = 1.22，= 0.005；呼吸困难，SMD = -0.92，<0.0001）、每次训练≤20分钟的IMT（吸气肌力量，SMD = 0.97，= 0.008；呼吸困难，SMD = -0.63，= 0.007；生活质量，SMD = 1.66，= 0.007）以及每周进行>3次的IMT（吸气肌力量，SMD = 1.06，<0.00001；呼吸困难，SMD = -0.54，<0.00001；生活质量，SMD = 0.48，= 0.0009）效果更佳。这项荟萃分析为临床医生提供了证据，支持建议COPD患者进行PImax<60%的IMT，每周超过3次，每次训练不超过20分钟，以改善吸气肌力量、呼吸困难和生活质量。
