Zhang Yuan, Lan Mengyi, Chen Yong
School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China.
Pharmaceutics. 2024 Oct 29;16(11):1394. doi: 10.3390/pharmaceutics16111394.
In the tenth year since the first edition of MISEV was released in 2014, MISEV2023 has been reported in 2024 with the aim of refining the standard and improving the rigor, reproducibility, and transparency of extracellular vesicle (EV) research to clarify the requirements for experimental design of EVs, emphasize the importance of reproducible experimental results as well as encouraging openness of experimental information. The release of MISEV has significantly contributed to the quality of research in the field of EVs, which creates a more reliable research environment. However, despite the important role of MISEV, there is still a need for the EV researchers to continue to push for the widespread implementation of the guidelines to meet the evolving nature and challenges of EV research. The evolution of EV research and the attention it receives have grown exponentially over time, as has the number of people involved in the writing of MISEV. Here, this review briefly summarizes the evolution of the three editions of MISEV, aiming to recall MISEV2014 and MISEV2018 while learning about the latest release, MISEV2023, to gain a deeper understanding of the content, and to provide a quick note for beginners who want to learn about MISEV and explore the EV world.
自2014年发布第一版《细胞外囊泡研究的最小信息标准》（MISEV）以来的第十年，2024年发布了MISEV2023，目的是完善标准，提高细胞外囊泡（EV）研究的严谨性、可重复性和透明度，以明确EV实验设计的要求，强调可重复实验结果的重要性，并鼓励实验信息的公开。MISEV的发布对EV领域的研究质量有显著贡献，营造了更可靠的研究环境。然而，尽管MISEV发挥了重要作用，但EV研究人员仍需继续推动这些指南的广泛实施，以应对EV研究不断变化的性质和挑战。随着时间的推移，EV研究的发展及其受到的关注呈指数级增长，参与撰写MISEV的人数也是如此。在此，本综述简要总结了MISEV三个版本的演变，旨在回顾MISEV2014和MISEV2018，同时了解最新版本MISEV2023，以更深入地理解其内容，并为想要了解MISEV并探索EV世界的初学者提供一份简要说明。
