对 SARS-CoV-2 的深入了解：用于 COVID-19 治疗的小分子杂合体。
Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment.
机构信息
Institute for Organic Synthesis and Photoreactivity (ISOF), National Research Council of Italy (CNR), 40129 Bologna, Italy.
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
出版信息
Molecules. 2024 Nov 15;29(22):5403. doi: 10.3390/molecules29225403.
The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral -SARS-CoV-2 activity.
治疗方式结合两种或多种具有不同作用机制的治疗剂具有优势，这促使人们研究具有混合功能的化合物在药理学方面的应用。分子杂交是通过两个或多个药效团单元的共价结合而产生的，它已成为克服多个问题的一种很有前途的方法，并且也被探索用于设计治疗 COVID-19 的新药。在这篇综述中，我们介绍了迄今为止文献中报道的天然产物和合成来源的小分子杂合物的概述，这些杂合物具有潜在的抗 SARS-CoV-2 病毒活性。
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