Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy.
Department of Chemical and Geological Sciences, University of Cagliari, S.P. 8 CA, 09042 Cagliari, Italy.
Biomolecules. 2023 Sep 2;13(9):1339. doi: 10.3390/biom13091339.
The main protease (M) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of M produces a detrimental effect on the course of the infection, making this target one of the most attractive for the treatment of COVID-19. The current success of the SARS-CoV-2 M inhibitor Nirmatrelvir, the first oral drug for the treatment of severe forms of COVID-19, has further focused the attention of researchers on this important viral target, making the search for new M inhibitors a thriving and exciting field for the development of antiviral drugs active against SARS-CoV-2 and related coronaviruses.
主蛋白酶（M）在严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）的复制中起着关键作用，被认为是一个高度保守的病毒靶标。破坏 M 的催化活性对感染过程产生不利影响，使该靶标成为 COVID-19 治疗的最有吸引力的靶标之一。目前，SARS-CoV-2 M 抑制剂奈玛特韦（Nirmatrelvir）的成功，该药是治疗 COVID-19 严重形式的第一种口服药物，进一步引起了研究人员对这一重要病毒靶标的关注，使寻找新的 M 抑制剂成为开发针对 SARS-CoV-2 和相关冠状病毒的抗病毒药物的一个充满活力和令人兴奋的领域。
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